DegronMD

Uniprot ID: Q8IYM0

Source protein: Protein FAM186B

Source gene: FAM186B

Class: DEG_SPOP_SBC_1

Location: 859:863

E3 ligase: SPOP

DEGRON score: 0.9006

ASA_SCORE: 57.08

COIL: 0.5404

CONS_SCORE: 0.8546

DSS_SCORE: 0.3463

HELIX: 0.277

FCONS_SCORE: 1.0556

RIG_SCORE: 0.7384

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S863G	TCGA-D1-A1NZ	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	0.6993
p.S863G	DO41536	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	0.6993
p.M851T	SIDM00321	Ovarian Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.M851T	SIDM00351	Oral Cavity Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.M851T	ACH-000430	Ovarian Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.1111
p.M851T	ACH-002029	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.1111
p.M851T	SAS	upper_aerodigestive_tract	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1111
p.M851T	TYK-nu	ovary	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1111
p.E852D	SIDM00789	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1389
p.E852D	SIDM00794	Other Solid Cancers	GDSC	VASSS	DEG_SPOP_SBC_1	0.1389
p.E852D	SIDM00179	Melanoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1389
p.E852D	SIDM00044	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1389
p.A865T	SIDM00832	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.2778
p.A865T	ACH-000680	Colon/Colorectal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.2778
p.A865T	SW948	large_intestine	COSMIC	VASSS	DEG_SPOP_SBC_1	0.2778
p.I866K	SIDM01619	Endometrial Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.25
p.I866K	ACH-000984	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	63:67	VASSS	SPOP	0.9895	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2071:2075	VASSS	SPOP	0.8357	More...
P57058	Hormonally up-regulated neu tumor-associated kinase	DEG_SPOP_SBC_1	513:517	VASSS	SPOP	0.9759	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2973:2977	VASSS	SPOP	0.9629	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	290:294	VASSS	SPOP	0.9979	More...
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_SPOP_SBC_1	387:391	VASSS	SPOP	0.9672	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	187:191	VASSS	SPOP	0.9697	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1052:1056	VASSS	SPOP	0.9974	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1202:1206	VASSS	SPOP	0.9307	More...
Q5SNT2	Transmembrane protein 201	DEG_SPOP_SBC_1	514:518	VASSS	SPOP	0.9614	More...
Q5T0W9	Protein FAM83B	DEG_SPOP_SBC_1	425:429	VASSS	SPOP	0.9994	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1700:1704	VASSS	SPOP	0.9907	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	931:935	VASSS	SPOP	0.6437	More...
Q86Y91	Kinesin-like protein KIF18B	DEG_SPOP_SBC_1	787:791	VASSS	SPOP	0.9955	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	351:355	VASSS	SPOP	0.9052	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	445:449	VASSS	SPOP	0.6862	More...
Q96L93	Kinesin-like protein KIF16B	DEG_SPOP_SBC_1	1096:1100	VASSS	SPOP	0.9957	More...
Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14	DEG_SPOP_SBC_1	196:200	VASSS	SPOP	0.6707	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1040:1044	VASSS	SPOP	0.9979	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	570:574	VASSS	SPOP	0.9829	More...
Q9NRR6	Phosphatidylinositol polyphosphate 5-phosphatase type IV	DEG_SPOP_SBC_1	164:168	VASSS	SPOP	0.9986	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	888:892	VASSS	SPOP	0.8649	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_SPOP_SBC_1	327:331	VASSS	SPOP	0.9253	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1391:1395	VASSS	SPOP	0.9996	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1037:1041	VASSS	SPOP	0.5544	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	230:234	VASSS	SPOP	0.9994	More...
Q8IYM0	Protein FAM186B	DEG_SPOP_SBC_1	859:863	VASSS	SPOP	0.9006	More...
Q9BWW9	Apolipoprotein L5	DEG_SPOP_SBC_1	140:144	VASSS	SPOP	0.5682	More...
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_SPOP_SBC_1	247:251	VASSS	SPOP	0.9642	More...
Q5SVZ6	Zinc finger MYM-type protein 1	DEG_SPOP_SBC_1	395:399	VASSS	SPOP	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASSS

Degron related mutations and impact score

Drug responses associated with FAM186B mutations

All proteins holding degron of VASSS