DegronMD - Q53LP3(SOWAHC)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K427R	TCGA-37-4141	LUSC	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation substituting flanking lysine	0.2222
p.K427R	DO26862	LUSC	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation substituting flanking lysine	0.2222
p.V418M	TCGA-A5-A0G2	UCEC	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.6097
p.V418M	DO41235	UCEC	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.6097
p.R412H	TCGA-B5-A11E	UCEC	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.8244
p.R412H	DO41644	UCEC	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.8244
p.G402V	TCGA-ER-A19J	SKCM	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.0833
p.G402V	DO37426	SKCM	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.0833
p.G409S	TCGA-SW-A7EA	STAD	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.2778
p.G409S	DO51749	STAD	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.2778
p.V247M	DO35132	PACA	ICGC	VASSS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7208
p.E253D	DO232761	PBCA	ICGC	VASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2778
p.V418G	DO219879	SKCA	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.7532
p.G407V	SIDM00971	Breast Carcinoma	GDSC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.2222
p.G407V	ACH-000828	Breast Cancer	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.2222
p.G407V	ZR-75-30	breast	COSMIC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.2222
p.A406V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.1944
p.A406V	ACH-001738	Leukemia	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.1944
p.A406V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.1944
p.P420A	SIDM01050	Biliary Tract Carcinoma	GDSC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.3056
p.P420A	ACH-001494	Bile Duct Cancer	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.3056
p.P420A	EGI-1	biliary tract	COSMIC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.3056
p.G411E	SIDM00150	Colorectal Carcinoma	GDSC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.6087
p.G411E	ACH-000969	Colon/Colorectal Cancer	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.6087
p.G411E	KM12	large intestine	COSMIC	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.6087
p.R412L	ACH-000049	Non-Cancerous	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.8428

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOWAHC

UniProt ID: Q53LP3

Entrez ID: 65124

Protein name: Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOWAHC in