DegronMD

Uniprot ID: Q53LP3

Source protein: Ankyrin repeat domain-containing protein SOWAHC

Source gene: SOWAHC

Class: DEG_APCC_DBOX_1

Location: 411:419

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9872

ASA_SCORE: 63.6444

COIL: 0.5492

CONS_SCORE: 0.489

DSS_SCORE: 0.3539

HELIX: 0.3712

FCONS_SCORE: 1.0942

RIG_SCORE: 0.756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K427R	TCGA-37-4141	LUSC	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	0.2222
p.K427R	DO26862	LUSC	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	0.2222
p.V418M	TCGA-A5-A0G2	UCEC	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	0.6097
p.V418M	DO41235	UCEC	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	0.6097
p.R412H	TCGA-B5-A11E	UCEC	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	0.8244
p.R412H	DO41644	UCEC	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	0.8244
p.G402V	TCGA-ER-A19J	SKCM	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	0.0833
p.G402V	DO37426	SKCM	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	0.0833
p.G409S	TCGA-SW-A7EA	STAD	TCGA	GRWRLSKVL	DEG_APCC_DBOX_1	0.2778
p.G409S	DO51749	STAD	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	0.2778
p.V418G	DO219879	SKCA	ICGC	GRWRLSKVL	DEG_APCC_DBOX_1	0.7532
p.G407V	SIDM00971	Breast Carcinoma	GDSC	GRWRLSKVL	DEG_APCC_DBOX_1	0.2222
p.G407V	ACH-000828	Breast Cancer	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	0.2222
p.G407V	ZR-75-30	breast	COSMIC	GRWRLSKVL	DEG_APCC_DBOX_1	0.2222
p.A406V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	GRWRLSKVL	DEG_APCC_DBOX_1	0.1944
p.A406V	ACH-001738	Leukemia	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	0.1944
p.A406V	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	GRWRLSKVL	DEG_APCC_DBOX_1	0.1944
p.P420A	SIDM01050	Biliary Tract Carcinoma	GDSC	GRWRLSKVL	DEG_APCC_DBOX_1	0.3056
p.P420A	ACH-001494	Bile Duct Cancer	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	0.3056
p.P420A	EGI-1	biliary_tract	COSMIC	GRWRLSKVL	DEG_APCC_DBOX_1	0.3056
p.G411E	SIDM00150	Colorectal Carcinoma	GDSC	GRWRLSKVL	DEG_APCC_DBOX_1	0.6087
p.G411E	ACH-000969	Colon/Colorectal Cancer	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	0.6087
p.G411E	KM12	large_intestine	COSMIC	GRWRLSKVL	DEG_APCC_DBOX_1	0.6087
p.R412L	ACH-000049	Non-Cancerous	CCLE	GRWRLSKVL	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_APCC_DBOX_1	411:419	GRWRLSKVL	APC,CDC20,FZR1	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRWRLSKVL

Degron related mutations and impact score

Drug responses associated with SOWAHC mutations

All proteins holding degron of GRWRLSKVL