DegronMD

Uniprot ID: Q5JUK3

Source protein: Potassium channel subfamily T member 1

Source gene: KCNT1

Class: DEG_SPOP_SBC_1

Location: 1028:1032

E3 ligase: SPOP

DEGRON score: 0.9188

ASA_SCORE: 71.48

COIL: 0.803

CONS_SCORE: 0.286

DSS_SCORE: 0.3077

HELIX: 0.0818

FCONS_SCORE: 0.7287

RIG_SCORE: 0.7486

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1024H	TCGA-12-5299	GBM	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2222
p.R1020H	TCGA-DC-6160	READ	TCGA	VFSTS	DEG_SPOP_SBC_1	0.1111
p.R1020H	SIDM00217	Colorectal Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.1111
p.R1020H	SNU-1040	large_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.1111
p.G1039D	TCGA-E2-A155	BRCA	TCGA	VFSTS	DEG_SPOP_SBC_1	0.1389
p.D1033N	DO51925	BLCA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.3056
p.E1023K	DO219041	BLCA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.1944
p.G1018D	DO1707	BRCA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.0556
p.P1031R	DO23504	LINC	ICGC	VFSTS	DEG_SPOP_SBC_1	0.7512
p.S1028F	DO37941	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	0.7982
p.P1031L	DO42033	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	0.7582
p.R1024C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VFSTS	DEG_SPOP_SBC_1	0.2222
p.R1024C	ACH-002059	Leukemia	CCLE	VFSTS	DEG_SPOP_SBC_1	0.2222
p.R1024C	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.2222
p.S1032F	SIDM00414	Bladder Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.7982
p.S1032F	ACH-000545	Bladder Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.7982
p.S1032F	VM-CUB-1	urinary_tract	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.7982
p.R1020S	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.1111
p.R1020S	ACH-000416	Lung Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.1111
p.R1020S	NCI-H838	lung	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.1111
p.V1027M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.3056
p.S1018L	HUTU-80	small_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.0556
p.E1031K	SNU-1040	large_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.7022
p.V1033M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.3056
p.S1030L	HUTU-80	small_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.7667
p.S1032L	HUTU-80	small_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.7667
p.E1033K	SNU-1040	large_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.3056
p.V1021M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.1389
p.V1040M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.1111
p.E1019K	SNU-1040	large_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31274	Homeobox protein Hox-C9	DEG_SPOP_SBC_1	61:65	VFSTS	SPOP	0.5518	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SPOP_SBC_1	411:415	VFSTS	SPOP	0.5201	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1028:1032	VFSTS	SPOP	0.9188	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_SPOP_SBC_1	1318:1322	VFSTS	SPOP	0.9967	More...
Q99594	Transcriptional enhancer factor TEF-5	DEG_SPOP_SBC_1	154:158	VFSTS	SPOP	0.9993	More...
Q9UMZ2	Synergin gamma	DEG_SPOP_SBC_1	636:640	VFSTS	SPOP	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VFSTS

Degron related mutations and impact score

Drug responses associated with KCNT1 mutations

All proteins holding degron of VFSTS