DegronMD

Uniprot ID: P31274

Source protein: Homeobox protein Hox-C9

Source gene: HOXC9

Class: DEG_SPOP_SBC_1

Location: 61:65

E3 ligase: SPOP

DEGRON score: 0.5518

ASA_SCORE: 52.3

COIL: 0.8344

CONS_SCORE: 0.7227

DSS_SCORE: 0.2493

HELIX: 0.0538

FCONS_SCORE: 1.044

RIG_SCORE: 0.7368

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A67T	TCGA-05-4420	LUAD	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2778
p.A67T	DO24675	LUAD	ICGC	VFSTS	DEG_SPOP_SBC_1	0.2778
p.A56T	TCGA-AJ-A3BD	UCEC	TCGA	VFSTS	DEG_SPOP_SBC_1	0.1944
p.A56T	TCGA-DF-A2KU	UCEC	TCGA	VFSTS	DEG_SPOP_SBC_1	0.1944
p.A56T	DO40813	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	0.1944
p.A56T	DO223286	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	0.1944
p.P51L	TCGA-AX-A0J1	UCEC	TCGA	VFSTS	DEG_SPOP_SBC_1	0.0556
p.P51L	DO41199	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	0.0556
p.S73L	TCGA-AX-A2HC	UCEC	TCGA	VFSTS	DEG_SPOP_SBC_1	0.1111
p.S73L	DO41572	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	0.1111
p.A56V	TCGA-BR-4363	STAD	TCGA	VFSTS	DEG_SPOP_SBC_1	0.1944
p.A56V	DO38815	STAD	ICGC	VFSTS	DEG_SPOP_SBC_1	0.1944
p.P57L	TCGA-IB-7651	PAAD	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2222
p.P57L	DO46657	PAAD	ICGC	VFSTS	DEG_SPOP_SBC_1	0.2222
p.A67V	TCGA-L5-A8NM	ESCA	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2778
p.A67V	SIDM00839	Colorectal Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.2778
p.A67V	ACH-000950	Colon/Colorectal Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.2778
p.A67V	LoVo	large_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.2778
p.T64M	DO233205	GACA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.7423
p.V75M	DO233772	GACA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.0556
p.F62L	ACH-000975	Lung Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31274	Homeobox protein Hox-C9	DEG_SPOP_SBC_1	61:65	VFSTS	SPOP	0.5518	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SPOP_SBC_1	411:415	VFSTS	SPOP	0.5201	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1028:1032	VFSTS	SPOP	0.9188	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_SPOP_SBC_1	1318:1322	VFSTS	SPOP	0.9967	More...
Q99594	Transcriptional enhancer factor TEF-5	DEG_SPOP_SBC_1	154:158	VFSTS	SPOP	0.9993	More...
Q9UMZ2	Synergin gamma	DEG_SPOP_SBC_1	636:640	VFSTS	SPOP	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons