DegronMD - Q9UMZ2(SYNRG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A657S	TCGA-AX-A06F	UCEC	TCGA	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation rewiring degron network	0.1111
p.T654I	TCGA-CL-4957	READ	TCGA	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation rewiring degron network	0.1944
p.A653T	TCGA-MT-A67F	HNSC	TCGA	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation rewiring degron network	0.2222
p.E638K	DO219909	DLBC	ICGC	VFSTS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7022
p.K654T	DO51189	LUAD	ICGC	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation rewiring degron network	0.1944
p.P644S	DO51280	SKCM	ICGC	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation altering degron motif	0.6752
p.S647N	DO42280	UCEC	ICGC	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation altering degron motif	0.7069
p.A657T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation rewiring degron network	0.1111
p.K641E	SIDM00329	Hodgkin's Lymphoma	GDSC	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation rewiring degron network	0.2778
p.K641E	SIDM00329	Hodgkin's Lymphoma	GDSC	VFSTS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.3056
p.D635N	ACH-002029	Head and Neck Cancer	CCLE	VSTPQST	DEG_SCF_FBW7_1	643:649	Mutation rewiring degron network	0.1111
p.D635N	ACH-002029	Head and Neck Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons