DegronMD

Uniprot ID: Q9UMZ2

Source protein: Synergin gamma

Source gene: SYNRG

Class: DEG_SCF_FBW7_1

Location: 643:649

E3 ligase: FBXW7

DEGRON score: 0.9695

ASA_SCORE: 84.4714

COIL: 0.9483

CONS_SCORE: 0.3518

DSS_SCORE: 0.337

HELIX: 0.0261

FCONS_SCORE: 1.0316

RIG_SCORE: 0.652

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A657S	TCGA-AX-A06F	UCEC	TCGA	VSTPQST	DEG_SCF_FBW7_1	0.1111
p.T654I	TCGA-CL-4957	READ	TCGA	VSTPQST	DEG_SCF_FBW7_1	0.1944
p.A653T	TCGA-MT-A67F	HNSC	TCGA	VSTPQST	DEG_SCF_FBW7_1	0.2222
p.K654T	DO51189	LUAD	ICGC	VSTPQST	DEG_SCF_FBW7_1	0.1944
p.P644S	DO51280	SKCM	ICGC	VSTPQST	DEG_SCF_FBW7_1	0.6752
p.S647N	DO42280	UCEC	ICGC	VSTPQST	DEG_SCF_FBW7_1	0.7069
p.A657T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VSTPQST	DEG_SCF_FBW7_1	0.1111
p.K641E	SIDM00329	Hodgkin's Lymphoma	GDSC	VSTPQST	DEG_SCF_FBW7_1	0.2778
p.D635N	ACH-002029	Head and Neck Cancer	CCLE	VSTPQST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMZ2	Synergin gamma	DEG_SCF_FBW7_1	643:649	VSTPQST	FBXW7	0.9695	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons