DegronMD

Uniprot ID: Q9UMZ2

Source protein: Synergin gamma

Source gene: SYNRG

Class: DEG_SPOP_SBC_1

Location: 636:640

E3 ligase: SPOP

DEGRON score: 0.9936

ASA_SCORE: 75.16

COIL: 0.7896

CONS_SCORE: 0.3417

DSS_SCORE: 0.3105

HELIX: 0.1174

FCONS_SCORE: 0.9784

RIG_SCORE: 0.7248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E638K	DO219909	DLBC	ICGC	VFSTS	DEG_SPOP_SBC_1	0.7022
p.K641E	SIDM00329	Hodgkin's Lymphoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.3056
p.D635N	ACH-002029	Head and Neck Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31274	Homeobox protein Hox-C9	DEG_SPOP_SBC_1	61:65	VFSTS	SPOP	0.5518	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SPOP_SBC_1	411:415	VFSTS	SPOP	0.5201	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1028:1032	VFSTS	SPOP	0.9188	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_SPOP_SBC_1	1318:1322	VFSTS	SPOP	0.9967	More...
Q99594	Transcriptional enhancer factor TEF-5	DEG_SPOP_SBC_1	154:158	VFSTS	SPOP	0.9993	More...
Q9UMZ2	Synergin gamma	DEG_SPOP_SBC_1	636:640	VFSTS	SPOP	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons