DegronMD - P31274(HOXC9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A67T	TCGA-05-4420	LUAD	TCGA	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2778
p.A67T	DO24675	LUAD	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2778
p.R91C	TCGA-86-A4JF	LUAD	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.2778
p.R91C	TCGA-A6-3809	COAD	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.2778
p.R91C	DO8722	COAD	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.2778
p.R91C	DO45317	LUAD	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.2778
p.A56T	TCGA-AJ-A3BD	UCEC	TCGA	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1944
p.A56T	TCGA-DF-A2KU	UCEC	TCGA	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1944
p.A56T	DO40813	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1944
p.A56T	DO223286	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1944
p.P51L	TCGA-AX-A0J1	UCEC	TCGA	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.0556
p.P51L	DO41199	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.0556
p.S73L	TCGA-AX-A2HC	UCEC	TCGA	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1111
p.S73L	DO41572	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1111
p.A56V	TCGA-BR-4363	STAD	TCGA	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1944
p.A56V	DO38815	STAD	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1944
p.S105T	TCGA-GU-AATP	BLCA	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.2222
p.S105T	DO51894	BLCA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.2222
p.A88T	TCGA-GV-A3JZ	BLCA	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1944
p.A88T	DO773	BLCA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1944
p.P57L	TCGA-IB-7651	PAAD	TCGA	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2222
p.P57L	DO46657	PAAD	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2222
p.A67V	TCGA-L5-A8NM	ESCA	TCGA	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2778
p.A67V	SIDM00839	Colorectal Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2778
p.A67V	ACH-000950	Colon/Colorectal Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2778
p.A67V	LoVo	large intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2778
p.Y92F	TCGA-NJ-A4YI	LUAD	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.3056
p.Y92F	DO218942	LUAD	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.3056
p.S108R	DO222891	COCA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1389
p.M93T	DO233179	GACA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.6312
p.T64M	DO233205	GACA	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation altering degron motif	0.7423
p.V75M	DO233772	GACA	ICGC	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.0556
p.P99S	DO233804	GACA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.5641
p.R94L	DO228948	LICA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.8428
p.G87R	SIDM01045	Endometrial Carcinoma	GDSC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1667
p.G87R	ACH-000978	Endometrial/Uterine Cancer	CCLE	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1667
p.G87R	EN	endometrium	COSMIC	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1667
p.V104I	ACH-000943	Colon/Colorectal Cancer	CCLE	MRTWLEPLS	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.25
p.F62L	ACH-000975	Lung Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	61:65	Mutation altering degron motif	0.587

Kaplan plot for HOXC9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXC9

UniProt ID: P31274

Entrez ID: 3225

Protein name: Homeobox protein Hox-C9 (Homeobox protein Hox-3B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXC9 in