DegronMD

Uniprot ID: P31274

Source protein: Homeobox protein Hox-C9

Source gene: HOXC9

Class: DEG_APCC_DBOX_1

Location: 93:101

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8173

ASA_SCORE: 50.6556

COIL: 0.7599

CONS_SCORE: 0.6915

DSS_SCORE: 0.2401

HELIX: 0.1231

FCONS_SCORE: 1.222

RIG_SCORE: 0.8259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R91C	TCGA-86-A4JF	LUAD	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	0.2778
p.R91C	TCGA-A6-3809	COAD	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	0.2778
p.R91C	DO8722	COAD	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.2778
p.R91C	DO45317	LUAD	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.2778
p.S105T	TCGA-GU-AATP	BLCA	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	0.2222
p.S105T	DO51894	BLCA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.2222
p.A88T	TCGA-GV-A3JZ	BLCA	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	0.1944
p.A88T	DO773	BLCA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.1944
p.Y92F	TCGA-NJ-A4YI	LUAD	TCGA	MRTWLEPLS	DEG_APCC_DBOX_1	0.3056
p.Y92F	DO218942	LUAD	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.3056
p.S108R	DO222891	COCA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.1389
p.M93T	DO233179	GACA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.6312
p.P99S	DO233804	GACA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.5641
p.R94L	DO228948	LICA	ICGC	MRTWLEPLS	DEG_APCC_DBOX_1	0.8428
p.G87R	SIDM01045	Endometrial Carcinoma	GDSC	MRTWLEPLS	DEG_APCC_DBOX_1	0.1667
p.G87R	ACH-000978	Endometrial/Uterine Cancer	CCLE	MRTWLEPLS	DEG_APCC_DBOX_1	0.1667
p.G87R	EN	endometrium	COSMIC	MRTWLEPLS	DEG_APCC_DBOX_1	0.1667
p.V104I	ACH-000943	Colon/Colorectal Cancer	CCLE	MRTWLEPLS	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31274	Homeobox protein Hox-C9	DEG_APCC_DBOX_1	93:101	MRTWLEPLS	APC,CDC20,FZR1	0.8173	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons