DegronMD - Q99594(TEAD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P206S	TCGA-17-Z011	LUAD	TCGA	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation altering degron motif	0.5641
p.R160W	TCGA-A6-6654	COAD	TCGA	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2778
p.R160W	DO9498	COAD	ICGC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2778
p.R160W	SIDM00596	Endometrial Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2778
p.R160W	HEC-1	endometrium	COSMIC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2778
p.L168V	TCGA-B6-A0RS	BRCA	TCGA	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.L168V	DO4012	BRCA	ICGC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.R218C	TCGA-D1-A103	UCEC	TCGA	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.2222
p.R218C	DO42312	UCEC	ICGC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.2222
p.R160Q	TCGA-DH-5144	LGG	TCGA	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2778
p.R160Q	DO22175	LGG	ICGC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2778
p.S156F	TCGA-EE-A2MJ	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7982
p.S156F	DO38099	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7982
p.P204L	TCGA-EJ-5524	PRAD	TCGA	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation altering degron motif	0.7582
p.P204L	DO36284	PRAD	ICGC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation altering degron motif	0.7582
p.S158F	TCGA-WE-A8ZX	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7982
p.S158F	DO51291	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7982
p.S223A	DO218796	BRCA	ICGC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.0833
p.A221P	DO50408	ESAD	ICGC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.1389
p.V214A	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation altering degron motif	0.6936
p.V214A	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation altering degron motif	0.6936
p.R218S	SIDM00953	Small Cell Lung Carcinoma	GDSC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.2222
p.R218S	CPC-N	lung	COSMIC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.2222
p.E200K	SIDM00161	Biliary Tract Carcinoma	GDSC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.2778
p.G192S	ACH-000300	Kidney Cancer	CCLE	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.0556
p.E204Q	ACH-000554	Breast Cancer	CCLE	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation altering degron motif	0.6744
p.R209C	ACH-000834	Bladder Cancer	CCLE	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation altering degron motif	0.8301
p.R158S	ACH-001049	Lung Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7427
p.R158S	CPC-N	lung	COSMIC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7427
p.D157E	ACH-001049	Lung Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.6758
p.D157E	CPC-N	lung	COSMIC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.6758
p.V154A	ACH-002272	Lymphoma	CCLE	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.5825
p.V154A	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.5825
p.D217E	CPC-N	lung	COSMIC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	202:214	Mutation rewiring degron network	0.25

Kaplan plot for TEAD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TEAD3

UniProt ID: Q99594

Entrez ID: 7005

Protein name: Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TEAD3 in