DegronMD

Uniprot ID: Q99594

Source protein: Transcriptional enhancer factor TEF-5

Source gene: TEAD3

Class: DEG_ODPH_VHL_1

Location: 202:214

E3 ligase: VHL

DEGRON score: 0.9541

ASA_SCORE: 52.7

COIL: 0.8108

CONS_SCORE: 0.396

DSS_SCORE: 0.2661

HELIX: 0.1171

FCONS_SCORE: 0.985

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P206S	TCGA-17-Z011	LUAD	TCGA	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.5641
p.R218C	TCGA-D1-A103	UCEC	TCGA	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.2222
p.R218C	DO42312	UCEC	ICGC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.2222
p.P204L	TCGA-EJ-5524	PRAD	TCGA	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.7582
p.P204L	DO36284	PRAD	ICGC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.7582
p.S223A	DO218796	BRCA	ICGC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.0833
p.A221P	DO50408	ESAD	ICGC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.1389
p.V214A	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.6936
p.V214A	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.6936
p.R218S	SIDM00953	Small Cell Lung Carcinoma	GDSC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.2222
p.R218S	CPC-N	lung	COSMIC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.2222
p.E200K	SIDM00161	Biliary Tract Carcinoma	GDSC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.2778
p.G192S	ACH-000300	Kidney Cancer	CCLE	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.0556
p.E204Q	ACH-000554	Breast Cancer	CCLE	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.6744
p.R209C	ACH-000834	Bladder Cancer	CCLE	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.8301
p.D217E	CPC-N	lung	COSMIC	LAPLPSAAASVPV	DEG_ODPH_VHL_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99594	Transcriptional enhancer factor TEF-5	DEG_ODPH_VHL_1	202:214	LAPLPSAAASVPV	VHL	0.9541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons