DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_SPOP_SBC_1

Location: 411:415

E3 ligase: SPOP

DEGRON score: 0.5201

ASA_SCORE: 86.74

COIL: 0.6872

CONS_SCORE: 0.4899

DSS_SCORE: 0.4273

HELIX: 0.0626

FCONS_SCORE: 0.9849

RIG_SCORE: 0.6925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T406A	TCGA-AD-5900	COAD	TCGA	VFSTS	DEG_SPOP_SBC_1	0.1944
p.T406A	DO8514	COAD	ICGC	VFSTS	DEG_SPOP_SBC_1	0.1944
p.T406A	DO227802	COCA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.1944
p.R402L	TCGA-ER-A19P	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	0.0833
p.R402L	DO47623	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	0.0833
p.Y407H	TCGA-IB-7651	PAAD	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2222
p.Y407H	DO46657	PAAD	ICGC	VFSTS	DEG_SPOP_SBC_1	0.2222
p.S423Y	DO229240	THCA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.1111
p.H408R	SIDM01293	Colorectal Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.25
p.I421V	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.1667
p.I421V	SIDM00142	Endometrial Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.1667
p.R402Q	SIDM00193	Colorectal Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.0833
p.R402Q	ACH-000991	Colon/Colorectal Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.0833
p.R402Q	SNU-81	large_intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31274	Homeobox protein Hox-C9	DEG_SPOP_SBC_1	61:65	VFSTS	SPOP	0.5518	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SPOP_SBC_1	411:415	VFSTS	SPOP	0.5201	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1028:1032	VFSTS	SPOP	0.9188	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_SPOP_SBC_1	1318:1322	VFSTS	SPOP	0.9967	More...
Q99594	Transcriptional enhancer factor TEF-5	DEG_SPOP_SBC_1	154:158	VFSTS	SPOP	0.9993	More...
Q9UMZ2	Synergin gamma	DEG_SPOP_SBC_1	636:640	VFSTS	SPOP	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons