DegronMD

Uniprot ID: P11137

Source protein: Microtubule-associated protein 2

Source gene: MAP2

Class: DEG_SCF_FBW7_1

Location: 1593:1599

E3 ligase: FBXW7

DEGRON score: 0.9949

ASA_SCORE: 90.6

COIL: 0.9614

CONS_SCORE: 0.7756

DSS_SCORE: 0.7886

HELIX: 0.0149

FCONS_SCORE: 1.0663

RIG_SCORE: 0.5649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1584I	TCGA-44-2659	LUAD	TCGA	PTTPGST	DEG_SCF_FBW7_1	0.0833
p.A1585T	TCGA-69-7979	LUAD	TCGA	PTTPGST	DEG_SCF_FBW7_1	0.1111
p.P1596L	TCGA-BF-AAP7	SKCM	TCGA	PTTPGST	DEG_SCF_FBW7_1	0.7582
p.R1583C	TCGA-CN-5369	HNSC	TCGA	PTTPGST	DEG_SCF_FBW7_1	0.0556
p.P1603S	TCGA-F4-6570	COAD	TCGA	PTTPGST	DEG_SCF_FBW7_1	0.2222
p.G1589D	TCGA-S9-A6WL	LGG	TCGA	PTTPGST	DEG_SCF_FBW7_1	0.2222
p.P1599S	DO10443	COAD	ICGC	PTTPGST	DEG_SCF_FBW7_1	0.6752
p.G1585D	DO48616	LGG	ICGC	PTTPGST	DEG_SCF_FBW7_1	0.1111
p.T1598S	DO25189	LUAD	ICGC	PTTPGST	DEG_SCF_FBW7_1	0.7116
p.T1601N	DO32964	PACA	ICGC	PTTPGST	DEG_SCF_FBW7_1	0.2778
p.P1592L	DO219472	SKCM	ICGC	PTTPGST	DEG_SCF_FBW7_1	0.75
p.P1603A	SIDM00820	Kidney Carcinoma	GDSC	PTTPGST	DEG_SCF_FBW7_1	0.2222
p.P1603A	ACH-002188	Kidney Cancer	CCLE	PTTPGST	DEG_SCF_FBW7_1	0.2222
p.P1603A	RCC-ER	kidney	COSMIC	PTTPGST	DEG_SCF_FBW7_1	0.2222
p.K1587N	SIDM00963	Breast Carcinoma	GDSC	PTTPGST	DEG_SCF_FBW7_1	0.2778
p.K1587N	ACH-000927	Breast Cancer	CCLE	PTTPGST	DEG_SCF_FBW7_1	0.2778
p.K1587N	BT-474	breast	COSMIC	PTTPGST	DEG_SCF_FBW7_1	0.2778
p.K1583N	BT-474	breast	COSMIC	PTTPGST	DEG_SCF_FBW7_1	0.0556
p.P1599A	RCC-ER	kidney	COSMIC	PTTPGST	DEG_SCF_FBW7_1	0.7503
p.S1604R	AGS	stomach	COSMIC	PTTPGST	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_SCF_FBW7_1	1593:1599	PTTPGST	FBXW7	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons