DegronMD

Uniprot ID: P11137

Source protein: Microtubule-associated protein 2

Source gene: MAP2

Class: DEG_APCC_DBOX_1

Location: 843:851

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9876

ASA_SCORE: 88.7889

COIL: 0.9309

CONS_SCORE: 0.4038

DSS_SCORE: 0.5124

HELIX: 0.0322

FCONS_SCORE: 0.7803

RIG_SCORE: 0.68

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E837Q	TCGA-09-2050	OV	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.1667
p.T845I	TCGA-12-0819	GBM	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.5966
p.K859N	TCGA-AA-3510	COAD	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.2222
p.R844H	TCGA-BR-7717	STAD	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.8244
p.R844H	TCGA-QL-A97D	COAD	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.8244
p.R844H	SIDM00596	Endometrial Carcinoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	0.8244
p.R844H	HEC-1	endometrium	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.8244
p.E837D	TCGA-EO-A22U	UCEC	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.1667
p.R844C	TCGA-F5-6814	READ	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.8301
p.R844C	SIDM00680	Colorectal Carcinoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	0.8301
p.R844C	LS-180	large_intestine	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.8301
p.S833L	TCGA-FW-A3TV	SKCM	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.5
p.S833L	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	0.5
p.S833L	ACH-000562	Lung Cancer	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	0.5
p.S833L	HCC-78	lung	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.5
p.T860M	TCGA-R6-A6XG	ESCA	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	0.5278
p.R840H	DO51732	COAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.R840H	DO50337	ESAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.R840H	DO234259	ESAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.R840H	DO38412	STAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.R840H	HEC-1	endometrium	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.K855N	DO7783	COAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.2222
p.V836I	DO233253	GACA	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.1389
p.G842C	DO233205	GACA	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.3056
p.T841I	DO13605	GBM	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.2778
p.P845S	DO220903	MELA	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.6752
p.V852I	DO220908	MELA	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.3056
p.E833Q	DO31869	OV	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.5
p.R840C	DO36556	READ	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.R840C	LS-180	large_intestine	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.E833D	DO43755	UCEC	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.5
p.L860I	DO41488	UCEC	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	0.5278
p.N854S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.N854S	ACH-002272	Lymphoma	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.N854S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.25
p.G846S	SIDM01112	Osteosarcoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	0.5882
p.G846S	ACH-000748	Bone Cancer	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	0.5882
p.G846S	SJSA-1	bone	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.5882
p.G846V	SIDM01112	Osteosarcoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	0.6421
p.G846V	ACH-000748	Bone Cancer	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	0.6421
p.G846V	SJSA-1	bone	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.6421
p.P848S	ACH-001786	Colon/Colorectal Cancer	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	0.5641
p.G842S	SJSA-1	bone	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.3056
p.N850S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.7069
p.S858G	KATOIII	stomach	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.1389
p.G842V	SJSA-1	bone	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRTGLPPVT

Degron related mutations and impact score

Drug responses associated with MAP2 mutations

All proteins holding degron of SRTGLPPVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_APCC_DBOX_1	843:851	SRTGLPPVT	APC,CDC20,FZR1	0.9876	More...