DegronMD

Uniprot ID: P11137

Source protein: Microtubule-associated protein 2

Source gene: MAP2

Class: DEG_SCF_FBW7_2

Location: 288:294

E3 ligase: FBXW7

DEGRON score: 0.977

ASA_SCORE: 107.0143

COIL: 0.9076

CONS_SCORE: 0.4517

DSS_SCORE: 0.5314

HELIX: 0.0411

FCONS_SCORE: 1.0292

RIG_SCORE: 0.6973

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D296Y	TCGA-A5-A0G2	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.2778
p.R293K	TCGA-AP-A0LM	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.6126
p.S285Y	TCGA-AX-A0J0	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.6944
p.S285Y	TCGA-BR-8680	STAD	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.6944
p.S285Y	TCGA-BS-A0UV	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.6944
p.K295Q	TCGA-B5-A0JY	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.3056
p.P286H	TCGA-E6-A1LX	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.2778
p.W278C	TCGA-G7-6797	KIRP	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.0556
p.P286S	TCGA-W3-A825	SKCM	TCGA	PLTPMRE	DEG_SCF_FBW7_2	0.2778
p.D296N	DO48362	BLCA	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.2778
p.P287S	DO222693	BTCA	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.3056
p.W300C	DO10324	COAD	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.1667
p.Q304H	DO50884	LICA	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.0556
p.P282S	DO51272	SKCM	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.1667
p.S281Y	DO47769	STAD	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.1389
p.S281Y	DO41133	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.1389
p.S281Y	DO42793	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.1389
p.R289K	DO43306	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.7237
p.P282H	DO41020	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.1667
p.K291Q	DO43041	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.6944
p.D292Y	DO41235	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	0.7325
p.P302Q	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	PLTPMRE	DEG_SCF_FBW7_2	0.1111
p.P302Q	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PLTPMRE	DEG_SCF_FBW7_2	0.1111
p.P302Q	ACH-000481	Lung Cancer	CCLE	PLTPMRE	DEG_SCF_FBW7_2	0.1111
p.P302Q	ACH-000892	Lung Cancer	CCLE	PLTPMRE	DEG_SCF_FBW7_2	0.1111
p.P302Q	NCI-H2170	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.1111
p.P302Q	NCI-H1563	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.1111
p.P283L	SIDM00217	Colorectal Carcinoma	GDSC	PLTPMRE	DEG_SCF_FBW7_2	0.1944
p.P283L	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTPMRE	DEG_SCF_FBW7_2	0.1944
p.P283L	SNU-1040	large_intestine	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.1944
p.D296V	ACH-001645	Skin Cancer	CCLE	PLTPMRE	DEG_SCF_FBW7_2	0.2778
p.V282L	NCI-H2135	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.1667
p.P279L	SNU-1040	large_intestine	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.0833
p.P298Q	NCI-H2170	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.2222
p.P298Q	NCI-H1563	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.2222
p.P294S	Sarc9371	bone	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.6752
p.K288N	BT-474	breast	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.6918
p.P304A	RCC-ER	kidney	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPMRE

Degron related mutations and impact score

Drug responses associated with MAP2 mutations

All proteins holding degron of PLTPMRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_SCF_FBW7_2	288:294	PLTPMRE	FBXW7	0.977	More...