DegronMD

Uniprot ID: P11137

Source protein: Microtubule-associated protein 2

Source gene: MAP2

Class: DEG_SCF_FBW7_1

Location: 1646:1653

E3 ligase: FBXW7

DEGRON score: 0.994

ASA_SCORE: 107.4875

COIL: 0.9631

CONS_SCORE: 0.5984

DSS_SCORE: 0.608

HELIX: 0.0113

FCONS_SCORE: 1.0165

RIG_SCORE: 0.6929

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1653H	DO37412	SKCM	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.7694
p.P1653L	DO220896	MELA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.7582
p.R1648C	TCGA-AX-A1CE	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.719
p.R1648H	TCGA-EA-A410	CESC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.7133
p.R1648H	TCGA-EO-A22U	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.7133
p.A1651V	DO8842	COAD	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.6936
p.A1651V	DO223286	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.6936
p.P1650S	ACH-002396	Bone Cancer	CCLE	IIRTPPKS	DEG_SCF_FBW7_1	0.6752
p.P1650S	Sarc9371	bone	COSMIC	IIRTPPKS	DEG_SCF_FBW7_1	0.6752
p.P1646S	Sarc9371	bone	COSMIC	IIRTPPKS	DEG_SCF_FBW7_1	0.6752
p.V1640A	DO36394	READ	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.6111
p.I1642N	DO228925	LICA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.3333
p.I1642S	DO23543	LIRI	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.3333
p.V1644A	TCGA-AG-3892	READ	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.A1655V	TCGA-AZ-4315	COAD	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.A1655V	TCGA-DF-A2KU	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.R1644H	DO49929	CESC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.R1644H	DO43755	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.R1644C	DO42280	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.P1657H	TCGA-FS-A1ZZ	SKCM	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.2222
p.R1657Q	DO52105	HNSC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2222
p.R1657Q	DO44911	LIHC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2222
p.A1641T	DO233825	GACA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.1944
p.I1659S	DO229446	SKCA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.1667
p.K1639T	DO10839	ESAD	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.1389

Showing 1 to 25 of 32 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_SCF_FBW7_1	1646:1653	IIRTPPKS	FBXW7	0.994	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons