DegronMD

Uniprot ID: P11137

Source protein: Microtubule-associated protein 2

Source gene: MAP2

Class: DEG_SCF_FBW7_1

Location: 1646:1653

E3 ligase: FBXW7

DEGRON score: 0.994

ASA_SCORE: 107.4875

COIL: 0.9631

CONS_SCORE: 0.5984

DSS_SCORE: 0.608

HELIX: 0.0113

FCONS_SCORE: 1.0165

RIG_SCORE: 0.6929

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1636F	TCGA-34-2604	LUSC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.0556
p.V1644A	TCGA-AG-3892	READ	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.R1648C	TCGA-AX-A1CE	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.719
p.A1655V	TCGA-AZ-4315	COAD	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.A1655V	TCGA-DF-A2KU	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.I1636V	TCGA-CD-5801	STAD	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.0556
p.R1648H	TCGA-EA-A410	CESC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.7133
p.R1648H	TCGA-EO-A22U	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.7133
p.P1657H	TCGA-FS-A1ZZ	SKCM	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.2222
p.R1661Q	TCGA-FV-A4ZP	LIHC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.1111
p.R1661Q	TCGA-UF-A719	HNSC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	0.1111
p.R1644H	DO49929	CESC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.R1644H	DO43755	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.A1651V	DO8842	COAD	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.6936
p.A1651V	DO223286	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.6936
p.K1639T	DO10839	ESAD	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.1389
p.A1641T	DO233825	GACA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.1944
p.R1657Q	DO52105	HNSC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2222
p.R1657Q	DO44911	LIHC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2222
p.I1642N	DO228925	LICA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.3333
p.I1642S	DO23543	LIRI	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.3333
p.P1653L	DO220896	MELA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.7582
p.V1640A	DO36394	READ	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.6111
p.I1659S	DO229446	SKCA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.1667
p.P1653H	DO37412	SKCM	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.7694
p.R1644C	DO42280	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	0.2778
p.V1638L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	IIRTPPKS	DEG_SCF_FBW7_1	0.1111
p.V1638L	ACH-001363	Lung Cancer	CCLE	IIRTPPKS	DEG_SCF_FBW7_1	0.1111
p.V1638L	NCI-H2135	lung	COSMIC	IIRTPPKS	DEG_SCF_FBW7_1	0.1111
p.P1650S	ACH-002396	Bone Cancer	CCLE	IIRTPPKS	DEG_SCF_FBW7_1	0.6752
p.P1650S	Sarc9371	bone	COSMIC	IIRTPPKS	DEG_SCF_FBW7_1	0.6752
p.P1646S	Sarc9371	bone	COSMIC	IIRTPPKS	DEG_SCF_FBW7_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IIRTPPKS

Degron related mutations and impact score

Drug responses associated with MAP2 mutations

All proteins holding degron of IIRTPPKS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_SCF_FBW7_1	1646:1653	IIRTPPKS	FBXW7	0.994	More...