DegronMD

Uniprot ID: P11137

Source protein: Microtubule-associated protein 2

Source gene: MAP2

Class: DEG_SCF_FBW7_2

Location: 747:754

E3 ligase: FBXW7

DEGRON score: 0.9728

ASA_SCORE: 87.575

COIL: 0.8665

CONS_SCORE: 0.6504

DSS_SCORE: 0.5505

HELIX: 0.0881

FCONS_SCORE: 1.1281

RIG_SCORE: 0.7317

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D744N	TCGA-85-A5B5	LUSC	TCGA	PATTPALE	DEG_SCF_FBW7_2	0.25
p.A748V	TCGA-AJ-A3BG	UCEC	TCGA	PATTPALE	DEG_SCF_FBW7_2	0.5825
p.P760H	TCGA-EB-A24C	SKCM	TCGA	PATTPALE	DEG_SCF_FBW7_2	0.1667
p.S763I	TCGA-FI-A2D5	UCEC	TCGA	PATTPALE	DEG_SCF_FBW7_2	0.0833
p.D740Y	DO234300	ESAD	ICGC	PATTPALE	DEG_SCF_FBW7_2	0.1389
p.A744V	DO233935	GACA	ICGC	PATTPALE	DEG_SCF_FBW7_2	0.25
p.A744V	DO42633	UCEC	ICGC	PATTPALE	DEG_SCF_FBW7_2	0.25
p.D740N	DO50102	LUSC	ICGC	PATTPALE	DEG_SCF_FBW7_2	0.1389
p.P756H	DO37438	SKCM	ICGC	PATTPALE	DEG_SCF_FBW7_2	0.2778
p.S759I	DO41331	UCEC	ICGC	PATTPALE	DEG_SCF_FBW7_2	0.1944
p.C758F	ACH-001028	Rhabdoid	CCLE	PATTPALE	DEG_SCF_FBW7_2	0.2222
p.Q764H	SNU-1040	large_intestine	COSMIC	PATTPALE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_SCF_FBW7_2	747:754	PATTPALE	FBXW7	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons