DegronMD

Uniprot ID: P11137

Source protein: Microtubule-associated protein 2

Source gene: MAP2

Class: DEG_APCC_DBOX_1

Location: 815:823

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8141

ASA_SCORE: 95.0556

COIL: 0.7622

CONS_SCORE: 0.6045

DSS_SCORE: 0.3797

HELIX: 0.1011

FCONS_SCORE: 0.9157

RIG_SCORE: 0.7388

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L812P	TCGA-60-2724	LUSC	TCGA	TRSRLASVS	DEG_APCC_DBOX_1	0.25
p.D811Y	TCGA-77-A5G1	LUSC	TCGA	TRSRLASVS	DEG_APCC_DBOX_1	0.2222
p.D825G	TCGA-DD-AADQ	LIHC	TCGA	TRSRLASVS	DEG_APCC_DBOX_1	0.2778
p.S833L	TCGA-FW-A3TV	SKCM	TCGA	TRSRLASVS	DEG_APCC_DBOX_1	0.5
p.S833L	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.5
p.S833L	ACH-000562	Lung Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	0.5
p.S833L	HCC-78	lung	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.5
p.A825S	DO228712	GACA	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.2778
p.A825S	HT-115	large_intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.2778
p.D821G	DO52244	LIHC	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.7198
p.L808P	DO26540	LUSC	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.1389
p.D807Y	DO50096	LUSC	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.1111
p.S829L	DO222810	MELA	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.S829L	DO38159	SKCM	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.S829L	HCC-78	lung	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.E833Q	DO31869	OV	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.5
p.A825V	DO229459	SKCA	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.2778
p.A825V	HT-115	large_intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.2778
p.E833D	DO43755	UCEC	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	0.5
p.D811H	SIDM02030	Colorectal Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.2222
p.R818I	SIDM00660	Colorectal Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.6991
p.R818I	ACH-000985	Colon/Colorectal Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	0.6991
p.R818I	LS-411N	large_intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.6991
p.M809T	SIDM01201	Other Blood Cancers	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.M809T	ACH-002289	Leukemia	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.M809T	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.A829S	SIDM00534	Colorectal Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.A829S	ACH-000986	Colon/Colorectal Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.A829S	HT-115	large_intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.A829V	SIDM00534	Colorectal Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.A829V	SIDM01612	Endometrial Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.A829V	ACH-000986	Colon/Colorectal Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.A829V	HT-115	large_intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.1667
p.R816M	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.8632
p.R816M	ACH-002337	Lung Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	0.8632
p.P807S	SIDM00861	Ovarian Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	0.1111
p.P807S	ES-2	ovary	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.1111
p.R814I	LS-411N	large_intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.3056
p.M805T	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRSRLASVS

Degron related mutations and impact score

Drug responses associated with MAP2 mutations

All proteins holding degron of TRSRLASVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_APCC_DBOX_1	815:823	TRSRLASVS	APC,CDC20,FZR1	0.8141	More...