DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPSY
Uniprot ID:
O15350
Source protein:
Tumor protein p73
Source gene:
TP73
Class:
ITCH
Location:
404:407
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9881
ASA_SCORE:
95.525
COIL:
0.9618
CONS_SCORE:
0.3489
DSS_SCORE:
0.6027
HELIX:
0.0215
FCONS_SCORE:
1.0851
RIG_SCORE:
0.5895
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.C406S
DO43907
UCEC
ICGC
PPSY
ITCH
0.7541
p.P407S
DO41999
UCEC
ICGC
PPSY
ITCH
0.6752
p.L402R
SIDM00999
Bladder Carcinoma
GDSC
PPSY
ITCH
0.2778
p.L402R
ACH-000973
Bladder Cancer
CCLE
PPSY
ITCH
0.2778
p.L402R
639-V
urinary_tract
COSMIC
PPSY
ITCH
0.2778
p.R401W
DO47253
SKCM
ICGC
PPSY
ITCH
0.25
p.A401T
SNU-175
large_intestine
COSMIC
PPSY
ITCH
0.25
p.A401T
MC-IXC
autonomic_ganglia
COSMIC
PPSY
ITCH
0.25
p.W401G
KARPAS-45
haematopoietic_and_lymphoid_tissue
COSMIC
PPSY
ITCH
0.25
p.P400R
DO47253
SKCM
ICGC
PPSY
ITCH
0.2222
p.Y412C
DO51407
PRAD
ICGC
PPSY
ITCH
0.1944
p.Y416H
LNCaP-Clone-FGC
prostate
COSMIC
PPSY
ITCH
0.1944
p.P413S
DO51276
SKCM
ICGC
PPSY
ITCH
0.1667
p.R414W
DO10582
COAD
ICGC
PPSY
ITCH
0.1389
p.R414W
DO41871
UCEC
ICGC
PPSY
ITCH
0.1389
p.R395C
HEC-1
endometrium
COSMIC
PPSY
ITCH
0.0833
Showing 1 to 16 of 16 entries
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Drug responses associated with TP73 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPSY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z5R6
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
ITCH
587:590
PPSY
ITCH,NEDD4
0.737
More...
Q96KQ4
Apoptosis-stimulating of p53 protein 1
ITCH
459:462
PPSY
ITCH,NEDD4
0.9751
More...
Q8N5I2
Arrestin domain-containing protein 1
ITCH
415:418
PPSY
ITCH,NEDD4
0.9903
More...
Q96B67
Arrestin domain-containing protein 3
ITCH
346:349
PPSY
ITCH,NEDD4
0.77
More...
Q96J65
ATP-binding cassette sub-family C member 12
ITCH
420:423
PPSY
ITCH,NEDD4
0.6228
More...
Q8N2M8
CLK4-associating serine/arginine rich protein
ITCH
286:289
PPSY
ITCH,NEDD4
0.9968
More...
A6NKD9
Coiled-coil domain-containing protein 85C
ITCH
316:319
PPSY
ITCH,NEDD4
0.9875
More...
Q99715
Collagen alpha-1
ITCH
2574:2577
PPSY
ITCH,NEDD4
0.6822
More...
Q96EP5
DAZ-associated protein 1
ITCH
370:373
PPSY
ITCH,NEDD4
0.9278
More...
Q9H7D0
Dedicator of cytokinesis protein 5
ITCH
1438:1441
PPSY
ITCH,NEDD4
0.5355
More...
O94850
Dendrin
ITCH
200:203
PPSY
ITCH,NEDD4
0.8751
More...
O94850
Dendrin
ITCH
230:233
PPSY
ITCH,NEDD4
0.9726
More...
Q9UBP4
Dickkopf-related protein 3
ITCH
91:94
PPSY
ITCH,NEDD4
0.9656
More...
Q9Y5R6
Doublesex- and mab-3-related transcription factor 1
ITCH
296:299
PPSY
ITCH,NEDD4
0.7856
More...
P11161
E3 SUMO-protein ligase EGR2
ITCH
205:208
PPSY
ITCH,NEDD4
0.9358
More...
Q7Z6E9
E3 ubiquitin-protein ligase RBBP6
ITCH
156:159
PPSY
ITCH,NEDD4
0.9269
More...
Q9NT22
EMILIN-3
ITCH
160:163
PPSY
ITCH,NEDD4
0.9466
More...
Q9NRM1
Enamelin
ITCH
853:856
PPSY
ITCH,NEDD4
0.9682
More...
Q14511
Enhancer of filamentation 1
ITCH
109:112
PPSY
ITCH,NEDD4
0.9998
More...
Q6NXG1
Epithelial splicing regulatory protein 1
ITCH
554:557
PPSY
ITCH,NEDD4
0.6605
More...
P19235
Erythropoietin receptor
ITCH
501:504
PPSY
ITCH,NEDD4
0.9994
More...
Q53EP0
Fibronectin type III domain-containing protein 3B
ITCH
110:113
PPSY
ITCH,NEDD4
0.9629
More...
Q5HY92
Fidgetin
ITCH
401:404
PPSY
ITCH,NEDD4
0.9941
More...
Q9BQQ3
Golgi reassembly-stacking protein 1
ITCH
206:209
PPSY
ITCH,NEDD4
0.9258
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
714:717
PPSY
ITCH,NEDD4
0.9896
More...
Showing 1 to 25 of 127 entries
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