DegronMD - Q16825(PTPN21)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R446H	TCGA-AA-3715	COAD	TCGA	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.3056
p.R446H	TCGA-AA-3715	COAD	TCGA	PPSY	ITCH	442:445	Mutation rewiring degron network	0.3056
p.R446H	DO8018	COAD	ICGC	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.3056
p.R446H	DO8018	COAD	ICGC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.3056
p.R446H	DO233766	GACA	ICGC	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.3056
p.R446H	DO233766	GACA	ICGC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.3056
p.D929Y	TCGA-AA-3977	COAD	TCGA	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.D929Y	DO8730	COAD	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.I441M	TCGA-AJ-A3EK	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.1667
p.I441M	TCGA-AJ-A3EK	UCEC	TCGA	PPSY	ITCH	442:445	Mutation rewiring degron network	0.3056
p.I441M	DO41584	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.1667
p.I441M	DO41584	UCEC	ICGC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.3056
p.T578M	TCGA-AX-A3FT	UCEC	TCGA	PPPY	ITCH	566:569	Mutation blocking phosphorylation signal	0.5278
p.T578M	DO40801	UCEC	ICGC	PPPY	ITCH	566:569	Mutation blocking phosphorylation signal	0.5278
p.M558I	TCGA-BR-4361	STAD	TCGA	PPPY	ITCH	566:569	Mutation rewiring degron network	0.1111
p.M558I	DO38887	STAD	ICGC	PPPY	ITCH	566:569	Mutation rewiring degron network	0.1111
p.R559W	TCGA-BR-8487	STAD	TCGA	PPPY	ITCH	566:569	Mutation rewiring degron network	0.1389
p.R559W	DO47867	STAD	ICGC	PPPY	ITCH	566:569	Mutation rewiring degron network	0.1389
p.I557V	TCGA-CG-5721	STAD	TCGA	PPPY	ITCH	566:569	Mutation rewiring degron network	0.0833
p.I557V	DO38192	STAD	ICGC	PPPY	ITCH	566:569	Mutation rewiring degron network	0.0833
p.R460M	TCGA-D3-A1Q3	SKCM	TCGA	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.1111
p.R460M	DO47509	SKCM	ICGC	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.1111
p.P932L	TCGA-D6-6516	HNSC	TCGA	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation altering degron motif	0.6471
p.P932L	DO15623	HNSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation altering degron motif	0.6471
p.P932S	TCGA-D6-6516	HNSC	TCGA	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation altering degron motif	0.6752
p.P932S	DO15623	HNSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation altering degron motif	0.6752
p.R436W	TCGA-DK-A1A3	BLCA	TCGA	PPSY	ITCH	442:445	Mutation rewiring degron network	0.1667
p.R436W	TCGA-SJ-A6ZI	UCEC	TCGA	PPSY	ITCH	442:445	Mutation rewiring degron network	0.1667
p.R436W	DO558	BLCA	ICGC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.1667
p.R436W	DO219784	UCEC	ICGC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.1667
p.Q928K	TCGA-EE-A17Z	SKCM	TCGA	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.2778
p.Q928K	DO37921	SKCM	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.2778
p.A439T	TCGA-F4-6570	COAD	TCGA	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.1111
p.A439T	TCGA-F4-6570	COAD	TCGA	PPSY	ITCH	442:445	Mutation rewiring degron network	0.25
p.A439T	DO10443	COAD	ICGC	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.1111
p.A439T	DO10443	COAD	ICGC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.25
p.E452D	TCGA-IC-A6RE	ESCA	TCGA	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation altering degron motif	0.6758
p.K456M	TCGA-NC-A5HI	LUSC	TCGA	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation substituting flanking lysine	0.3333
p.K456M	DO45461	LUSC	ICGC	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation substituting flanking lysine	0.3333
p.E939K	TCGA-W3-A825	SKCM	TCGA	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.2222
p.E939K	DO51272	SKCM	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.2222
p.Y445H	DO222817	BTCA	ICGC	PPSY	ITCH	442:445	Mutation altering degron motif	0.7229
p.R924I	DO222762	COCA	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.1667
p.V936A	DO229013	COCA	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.V936A	DO229003	COCA	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.V936A	DO229505	LAML	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.V936A	DO230659	LAML	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.V936A	DO231140	LAML	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.V936A	DO230931	LUSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.V936A	DO230990	LUSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.V936A	DO52365	LUSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.3056
p.Y569S	DO223019	ESCA	ICGC	PPPY	ITCH	566:569	Mutation altering degron motif	0.712
p.Y569S	DO229133	THCA	ICGC	PPPY	ITCH	566:569	Mutation altering degron motif	0.712
p.T560K	DO228986	LICA	ICGC	PPPY	ITCH	566:569	Mutation rewiring degron network	0.1667
p.T560K	DO229031	LICA	ICGC	PPPY	ITCH	566:569	Mutation rewiring degron network	0.1667
p.F927L	DO229018	LICA	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.25
p.P571H	DO229019	LICA	ICGC	PPPY	ITCH	566:569	Mutation rewiring degron network	0.2778
p.P433Q	DO229019	LICA	ICGC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.0833
p.P442T	DO229028	LICA	ICGC	PPSY	ITCH	442:445	Mutation altering degron motif	0.7031
p.A922E	DO229038	LICA	ICGC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.1111
p.H437N	DO229038	LICA	ICGC	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation rewiring degron network	0.0556
p.H437N	DO229038	LICA	ICGC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.1944
p.Y569H	DO52685	MALY	ICGC	PPPY	ITCH	566:569	Mutation altering degron motif	0.7229
p.P568S	SIDM01175	Other Sarcomas	GDSC	PPPY	ITCH	566:569	Mutation altering degron motif	0.5641
p.P568S	ACH-002309	Sarcoma	CCLE	PPPY	ITCH	566:569	Mutation altering degron motif	0.5641
p.R436Q	SIDM00346	Chronic Myelogenous Leukemia	GDSC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.1667
p.R436Q	ACH-000301	Leukemia	CCLE	PPSY	ITCH	442:445	Mutation rewiring degron network	0.1667
p.R436Q	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	442:445	Mutation rewiring degron network	0.1667
p.R926Q	SIDM00534	Colorectal Carcinoma	GDSC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.2222
p.R926Q	ACH-000986	Colon/Colorectal Cancer	CCLE	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.2222
p.R926Q	HT-115	large intestine	COSMIC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.2222
p.P570R	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	566:569	Mutation rewiring degron network	0.3056
p.P570R	ACH-000681	Lung Cancer	CCLE	PPPY	ITCH	566:569	Mutation rewiring degron network	0.3056
p.P570R	ACH-002337	Lung Cancer	CCLE	PPPY	ITCH	566:569	Mutation rewiring degron network	0.3056
p.S444F	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSY	ITCH	442:445	Mutation altering degron motif	0.6871
p.S444F	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	442:445	Mutation altering degron motif	0.6871
p.D935Y	SIDM00008	Ovarian Carcinoma	GDSC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation altering degron motif	0.7325
p.D935Y	SIDM01575	Plasma Cell Myeloma	GDSC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation altering degron motif	0.7325
p.D935Y	ACH-000426	Myeloma	CCLE	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation altering degron motif	0.7325
p.D935Y	ACH-000796	Ovarian Cancer	CCLE	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation altering degron motif	0.7325
p.E920K	SIDM00170	Head and Neck Carcinoma	GDSC	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.0556
p.E920K	ACH-000682	Head and Neck Cancer	CCLE	VLPYDD	LIG_APCC_ABBA_1	930:935	Mutation rewiring degron network	0.0556
p.Y451N	ACH-001719	Ovarian Cancer	CCLE	PTPDYE	DEG_SCF_FBW7_2	447:452	Mutation altering degron motif	0.5948

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN21

UniProt ID: Q16825

Entrez ID: 11099

Protein name: Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN21 in