DegronMD

Uniprot ID: Q16825

Source protein: Tyrosine-protein phosphatase non-receptor type 21

Source gene: PTPN21

Class: LIG_APCC_ABBA_1

Location: 930:935

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9578

ASA_SCORE: 47.7

COIL: 0.8007

CONS_SCORE: 0.6789

DSS_SCORE: 0.3027

HELIX: 0.0765

FCONS_SCORE: 1.1994

RIG_SCORE: 0.8382

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D929Y	TCGA-AA-3977	COAD	TCGA	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.D929Y	DO8730	COAD	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.P932L	TCGA-D6-6516	HNSC	TCGA	VLPYDD	LIG_APCC_ABBA_1	0.6471
p.P932L	DO15623	HNSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.6471
p.P932S	TCGA-D6-6516	HNSC	TCGA	VLPYDD	LIG_APCC_ABBA_1	0.6752
p.P932S	DO15623	HNSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.6752
p.Q928K	TCGA-EE-A17Z	SKCM	TCGA	VLPYDD	LIG_APCC_ABBA_1	0.2778
p.Q928K	DO37921	SKCM	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.2778
p.E939K	TCGA-W3-A825	SKCM	TCGA	VLPYDD	LIG_APCC_ABBA_1	0.2222
p.E939K	DO51272	SKCM	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.2222
p.R924I	DO222762	COCA	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.1667
p.V936A	DO229013	COCA	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.V936A	DO229003	COCA	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.V936A	DO229505	LAML	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.V936A	DO230659	LAML	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.V936A	DO231140	LAML	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.V936A	DO230931	LUSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.V936A	DO230990	LUSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.V936A	DO52365	LUSC	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.3056
p.F927L	DO229018	LICA	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.25
p.A922E	DO229038	LICA	ICGC	VLPYDD	LIG_APCC_ABBA_1	0.1111
p.R926Q	SIDM00534	Colorectal Carcinoma	GDSC	VLPYDD	LIG_APCC_ABBA_1	0.2222
p.R926Q	ACH-000986	Colon/Colorectal Cancer	CCLE	VLPYDD	LIG_APCC_ABBA_1	0.2222
p.R926Q	HT-115	large_intestine	COSMIC	VLPYDD	LIG_APCC_ABBA_1	0.2222
p.D935Y	SIDM00008	Ovarian Carcinoma	GDSC	VLPYDD	LIG_APCC_ABBA_1	0.7325
p.D935Y	SIDM01575	Plasma Cell Myeloma	GDSC	VLPYDD	LIG_APCC_ABBA_1	0.7325
p.D935Y	ACH-000426	Myeloma	CCLE	VLPYDD	LIG_APCC_ABBA_1	0.7325
p.D935Y	ACH-000796	Ovarian Cancer	CCLE	VLPYDD	LIG_APCC_ABBA_1	0.7325
p.E920K	SIDM00170	Head and Neck Carcinoma	GDSC	VLPYDD	LIG_APCC_ABBA_1	0.0556
p.E920K	ACH-000682	Head and Neck Cancer	CCLE	VLPYDD	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLPYDD

Degron related mutations and impact score

Drug responses associated with PTPN21 mutations

All proteins holding degron of VLPYDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16825	Tyrosine-protein phosphatase non-receptor type 21	LIG_APCC_ABBA_1	930:935	VLPYDD	APC,CDC20,FZR1	0.9578	More...