DegronMD

Uniprot ID: Q16825

Source protein: Tyrosine-protein phosphatase non-receptor type 21

Source gene: PTPN21

Class: DEG_SCF_FBW7_2

Location: 447:452

E3 ligase: FBXW7

DEGRON score: 0.9932

ASA_SCORE: 87.1333

COIL: 0.6702

CONS_SCORE: 0.4335

DSS_SCORE: 0.5132

HELIX: 0.3197

FCONS_SCORE: 1.2479

RIG_SCORE: 0.7121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R446H	TCGA-AA-3715	COAD	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.3056
p.R446H	DO8018	COAD	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.3056
p.R446H	DO233766	GACA	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.3056
p.I441M	TCGA-AJ-A3EK	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.1667
p.I441M	DO41584	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.1667
p.R460M	TCGA-D3-A1Q3	SKCM	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.R460M	DO47509	SKCM	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A439T	TCGA-F4-6570	COAD	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A439T	DO10443	COAD	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.E452D	TCGA-IC-A6RE	ESCA	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.6758
p.K456M	TCGA-NC-A5HI	LUSC	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.3333
p.K456M	DO45461	LUSC	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.3333
p.H437N	DO229038	LICA	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.0556
p.Y451N	ACH-001719	Ovarian Cancer	CCLE	PTPDYE	DEG_SCF_FBW7_2	0.5948

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SCF_FBW7_2	441:446	PTPDYE	FBXW7	0.9995	More...
Q16825	Tyrosine-protein phosphatase non-receptor type 21	DEG_SCF_FBW7_2	447:452	PTPDYE	FBXW7	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons