DegronMD - Q15678(PTPN14)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R940P	TCGA-04-1341	OV	TCGA	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.2778
p.R940P	DO28017	OV	ICGC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.2778
p.N470S	TCGA-12-0818	GBM	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation rewiring degron network	0.0556
p.N470S	DO12892	GBM	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation rewiring degron network	0.0556
p.R454M	TCGA-61-2611	OV	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.8632
p.R454M	DO28641	OV	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.8632
p.E957V	TCGA-69-7978	LUAD	TCGA	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation altering degron motif	0.7693
p.E957V	DO24920	LUAD	ICGC	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation altering degron motif	0.7693
p.V436M	TCGA-A5-A0G2	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1944
p.V436M	DO41235	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1944
p.V436M	SIDM01181	Hepatocellular Carcinoma	GDSC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1944
p.V436M	ACH-000221	Liver Cancer	CCLE	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1944
p.V436M	SNU-398	liver	COSMIC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1944
p.P568S	TCGA-A8-A09T	BRCA	TCGA	PPPY	ITCH	567:570	Mutation altering degron motif	0.6752
p.P568S	DO2802	BRCA	ICGC	PPPY	ITCH	567:570	Mutation altering degron motif	0.6752
p.A934V	TCGA-AX-A0J0	UCEC	TCGA	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.1111
p.A934V	DO41133	UCEC	ICGC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.1111
p.L457M	TCGA-AX-A2HG	UCEC	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.5999
p.L457M	DO41337	UCEC	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.5999
p.P567L	TCGA-AX-A2IN	UCEC	TCGA	PPPY	ITCH	567:570	Mutation altering degron motif	0.7582
p.P567L	DO42328	UCEC	ICGC	PPPY	ITCH	567:570	Mutation altering degron motif	0.7582
p.N959S	TCGA-AZ-4315	COAD	TCGA	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation altering degron motif	0.5958
p.N959S	DO8842	COAD	ICGC	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation altering degron motif	0.5958
p.R572W	TCGA-AZ-6598	COAD	TCGA	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.25
p.R572W	TCGA-AZ-6598	COAD	TCGA	PPPY	ITCH	567:570	Mutation rewiring degron network	0.2778
p.R572W	TCGA-D5-6530	COAD	TCGA	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.25
p.R572W	TCGA-D5-6530	COAD	TCGA	PPPY	ITCH	567:570	Mutation rewiring degron network	0.2778
p.R572W	TCGA-DD-A11C	LIHC	TCGA	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.25
p.R572W	TCGA-DD-A11C	LIHC	TCGA	PPPY	ITCH	567:570	Mutation rewiring degron network	0.2778
p.R572W	TCGA-XD-AAUL	PAAD	TCGA	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.25
p.R572W	TCGA-XD-AAUL	PAAD	TCGA	PPPY	ITCH	567:570	Mutation rewiring degron network	0.2778
p.R572W	DO10276	COAD	ICGC	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.25
p.R572W	DO10276	COAD	ICGC	PPPY	ITCH	567:570	Mutation rewiring degron network	0.2778
p.R572W	DO8312	COAD	ICGC	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.25
p.R572W	DO8312	COAD	ICGC	PPPY	ITCH	567:570	Mutation rewiring degron network	0.2778
p.R572W	DO22917	LIHC	ICGC	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.25
p.R572W	DO22917	LIHC	ICGC	PPPY	ITCH	567:570	Mutation rewiring degron network	0.2778
p.R572W	DO51723	PAAD	ICGC	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.25
p.R572W	DO51723	PAAD	ICGC	PPPY	ITCH	567:570	Mutation rewiring degron network	0.2778
p.S465F	TCGA-AZ-6600	COAD	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation blocking phosphorylation signal	0.6389
p.S465F	DO10774	COAD	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation blocking phosphorylation signal	0.6389
p.A934T	TCGA-B0-5399	KIRC	TCGA	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.1111
p.A934T	DO19523	KIRC	ICGC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.1111
p.K560N	TCGA-B5-A11E	UCEC	TCGA	PPPY	ITCH	567:570	Mutation substituting flanking lysine	0.25
p.K560N	DO41644	UCEC	ICGC	PPPY	ITCH	567:570	Mutation substituting flanking lysine	0.25
p.R949Q	TCGA-BG-A0MQ	UCEC	TCGA	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation rewiring degron network	0.1667
p.R949Q	TCGA-BG-A0MQ	UCEC	TCGA	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.2778
p.R949Q	DO228416	LICA	ICGC	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation rewiring degron network	0.1667
p.R949Q	DO228416	LICA	ICGC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.2778
p.R949Q	DO41127	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation rewiring degron network	0.1667
p.R949Q	DO41127	UCEC	ICGC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.2778
p.P437S	TCGA-BR-7851	STAD	TCGA	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.2222
p.P437S	DO38711	STAD	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.2222
p.D444Y	TCGA-D1-A165	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation altering degron motif	0.6214
p.D444Y	DO41740	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation altering degron motif	0.6214
p.I435T	TCGA-DI-A1BU	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1667
p.I435T	DO42023	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1667
p.K453N	TCGA-DK-A2HX	BLCA	TCGA	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation substituting flanking lysine	0.25
p.K453N	DO473	BLCA	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation substituting flanking lysine	0.25
p.R450H	TCGA-EI-6882	READ	TCGA	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.2222
p.R450H	TCGA-EI-6882	READ	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation rewiring degron network	0.2222
p.R450H	DO36531	READ	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.2222
p.R450H	DO36531	READ	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation rewiring degron network	0.2222
p.R454W	TCGA-EO-A22R	UCEC	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.8634
p.R454W	DO42713	UCEC	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.8634
p.S438L	TCGA-EO-A22R	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.25
p.S438L	DO42713	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.25
p.L559F	TCGA-FF-A7CQ	DLBC	TCGA	PPPY	ITCH	567:570	Mutation rewiring degron network	0.1111
p.L559F	DO219893	DLBC	ICGC	PPPY	ITCH	567:570	Mutation rewiring degron network	0.1111
p.G754S	TCGA-FI-A2F4	UCEC	TCGA	PPEY	ITCH	749:752	Mutation rewiring degron network	0.2778
p.G754S	TCGA-KK-A59V	PRAD	TCGA	PPEY	ITCH	749:752	Mutation rewiring degron network	0.2778
p.G754S	DO51346	PRAD	ICGC	PPEY	ITCH	749:752	Mutation rewiring degron network	0.2778
p.G754S	DO43434	UCEC	ICGC	PPEY	ITCH	749:752	Mutation rewiring degron network	0.2778
p.T577A	TCGA-HU-A4GX	STAD	TCGA	PATST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.7139
p.T577A	DO47757	STAD	ICGC	PATST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.7139
p.A583T	TCGA-HU-A4H8	STAD	TCGA	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.2222
p.A583T	DO47869	STAD	ICGC	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.2222
p.R940C	TCGA-XF-A9SZ	BLCA	TCGA	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.2778
p.R940C	DO51919	BLCA	ICGC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.2778
p.N561K	TCGA-ZB-A96I	THYM	TCGA	PPPY	ITCH	567:570	Mutation rewiring degron network	0.1667
p.S584R	DO48376	BLCA	ICGC	PATST	DEG_SPOP_SBC_1	575:579	Mutation blocking phosphorylation signal	0.6389
p.G455R	DO223503	CLLE	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.6457
p.A433V	DO233634	GACA	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	SIDM01088	Endometrial Carcinoma	GDSC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	ACH-000583	Lymphoma	CCLE	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	ACH-000965	Endometrial/Uterine Cancer	CCLE	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	ACH-001638	Lymphoma	CCLE	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	RL95-2	endometrium	COSMIC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.A433V	MC116	haematopoietic and lymphoid tissue	COSMIC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.R743H	DO233652	GACA	ICGC	PPEY	ITCH	749:752	Mutation rewiring degron network	0.1667
p.T442N	DO229019	LICA	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation altering degron motif	0.7055
p.T960K	DO229041	LICA	ICGC	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation rewiring degron network	0.3056
p.T955N	DO229041	LICA	ICGC	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation altering degron motif	0.5944
p.P954T	DO229045	LICA	ICGC	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation rewiring degron network	0.3056
p.P954T	DO229045	LICA	ICGC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.1389
p.L469I	DO228253	MALY	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation rewiring degron network	0.0833
p.A433T	DO228613	MALY	ICGC	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.1111
p.R940H	DO35120	PACA	ICGC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.2778
p.Y562S	SIDM00264	Ewing's Sarcoma	GDSC	PPPY	ITCH	567:570	Mutation rewiring degron network	0.1944
p.Y562S	ES4	bone	COSMIC	PPPY	ITCH	567:570	Mutation rewiring degron network	0.1944
p.T459A	SIDM00631	Breast Carcinoma	GDSC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.6028
p.T459A	ACH-001358	Breast Cancer	CCLE	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.6028
p.T459A	MDA-MB-330	breast	COSMIC	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation altering degron motif	0.6028
p.R586C	SIDM00333	Endometrial Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.1389
p.R586C	ACH-000988	Endometrial/Uterine Cancer	CCLE	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.1389
p.R586C	MFE-319	endometrium	COSMIC	PATST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.1389
p.R936C	SIDM00214	Colorectal Carcinoma	GDSC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.1667
p.R936C	ACH-000955	Colon/Colorectal Cancer	CCLE	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.1667
p.R936C	SNU-407	large intestine	COSMIC	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.1667
p.Y752C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PPEY	ITCH	749:752	Mutation altering degron motif	0.7087
p.Y752C	ACH-000964	Leukemia	CCLE	PPEY	ITCH	749:752	Mutation altering degron motif	0.7087
p.T577S	SIDM00160	Biliary Tract Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.6005
p.T577S	ACH-000377	Bile Duct Cancer	CCLE	PATST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.6005
p.N948I	ACH-000872	Lung Cancer	CCLE	TKENN	DEG_APCC_KENBOX_2	955:959	Mutation rewiring degron network	0.1389
p.N948I	ACH-000872	Lung Cancer	CCLE	VVPYEE	LIG_APCC_ABBA_1	942:947	Mutation rewiring degron network	0.3056
p.R450L	ACH-001750	Sarcoma	CCLE	PTPDYE	DEG_SCF_FBW7_2	441:446	Mutation rewiring degron network	0.2222
p.R450L	ACH-001750	Sarcoma	CCLE	RGILHTD	LIG_APCC_ABBAyCdc20_2	454:460	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN14

UniProt ID: Q15678

Entrez ID: 5784

Protein name: Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN14 in