DegronMD

Uniprot ID: Q15678

Source protein: Tyrosine-protein phosphatase non-receptor type 14

Source gene: PTPN14

Class: LIG_APCC_ABBAyCdc20_2

Location: 454:460

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9854

ASA_SCORE: 93.2286

COIL: 0.8006

CONS_SCORE: 0.2781

DSS_SCORE: 0.5212

HELIX: 0.125

FCONS_SCORE: 0.7723

RIG_SCORE: 0.7523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N470S	TCGA-12-0818	GBM	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.N470S	DO12892	GBM	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R454M	TCGA-61-2611	OV	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.8632
p.R454M	DO28641	OV	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.8632
p.L457M	TCGA-AX-A2HG	UCEC	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.5999
p.L457M	DO41337	UCEC	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.5999
p.S465F	TCGA-AZ-6600	COAD	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.6389
p.S465F	DO10774	COAD	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.6389
p.R450H	TCGA-EI-6882	READ	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R450H	DO36531	READ	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R454W	TCGA-EO-A22R	UCEC	TCGA	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R454W	DO42713	UCEC	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.8634
p.G455R	DO223503	CLLE	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.6457
p.L469I	DO228253	MALY	ICGC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.T459A	SIDM00631	Breast Carcinoma	GDSC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.6028
p.T459A	ACH-001358	Breast Cancer	CCLE	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.6028
p.T459A	MDA-MB-330	breast	COSMIC	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.6028
p.R450L	ACH-001750	Sarcoma	CCLE	RGILHTD	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15678	Tyrosine-protein phosphatase non-receptor type 14	LIG_APCC_ABBAyCdc20_2	454:460	RGILHTD	APC,CDC20,FZR1	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons