DegronMD

Uniprot ID: Q15678

Source protein: Tyrosine-protein phosphatase non-receptor type 14

Source gene: PTPN14

Class: DEG_SPOP_SBC_1

Location: 575:579

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 73.72

COIL: 0.9132

CONS_SCORE: 0.4908

DSS_SCORE: 0.7141

HELIX: 0.034

FCONS_SCORE: 1.1859

RIG_SCORE: 0.5916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R572W	TCGA-AZ-6598	COAD	TCGA	PATST	DEG_SPOP_SBC_1	0.25
p.R572W	TCGA-D5-6530	COAD	TCGA	PATST	DEG_SPOP_SBC_1	0.25
p.R572W	TCGA-DD-A11C	LIHC	TCGA	PATST	DEG_SPOP_SBC_1	0.25
p.R572W	TCGA-XD-AAUL	PAAD	TCGA	PATST	DEG_SPOP_SBC_1	0.25
p.R572W	DO10276	COAD	ICGC	PATST	DEG_SPOP_SBC_1	0.25
p.R572W	DO8312	COAD	ICGC	PATST	DEG_SPOP_SBC_1	0.25
p.R572W	DO22917	LIHC	ICGC	PATST	DEG_SPOP_SBC_1	0.25
p.R572W	DO51723	PAAD	ICGC	PATST	DEG_SPOP_SBC_1	0.25
p.T577A	TCGA-HU-A4GX	STAD	TCGA	PATST	DEG_SPOP_SBC_1	0.7139
p.T577A	DO47757	STAD	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.A583T	TCGA-HU-A4H8	STAD	TCGA	PATST	DEG_SPOP_SBC_1	0.2222
p.A583T	DO47869	STAD	ICGC	PATST	DEG_SPOP_SBC_1	0.2222
p.S584R	DO48376	BLCA	ICGC	PATST	DEG_SPOP_SBC_1	0.6389
p.R586C	SIDM00333	Endometrial Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1389
p.R586C	ACH-000988	Endometrial/Uterine Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.1389
p.R586C	MFE-319	endometrium	COSMIC	PATST	DEG_SPOP_SBC_1	0.1389
p.T577S	SIDM00160	Biliary Tract Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.6005
p.T577S	ACH-000377	Bile Duct Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with PTPN14 mutations

All proteins holding degron of PATST