DegronMD - Q04637(EIF4G1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P169Q	TCGA-05-4396	LUAD	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.2778
p.S360C	TCGA-13-1507	OV	TCGA	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1389
p.M297I	TCGA-17-Z031	LUAD	TCGA	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.1389
p.G294E	TCGA-18-4083	LUSC	TCGA	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.0556
p.S267L	TCGA-19-5956	GBM	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.6556
p.S267L	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.6556
p.S348Y	TCGA-21-5782	LUSC	TCGA	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.712
p.P357L	TCGA-22-4604	LUSC	TCGA	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.2222
p.S276F	TCGA-30-1855	OV	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.I300M	TCGA-38-4632	LUAD	TCGA	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.2222
p.L352F	TCGA-55-6982	LUAD	TCGA	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.6981
p.L352F	TCGA-EE-A2MR	SKCM	TCGA	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.6981
p.D198Y	TCGA-66-2758	LUSC	TCGA	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.1111
p.A77T	TCGA-92-7341	LUSC	TCGA	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.6028
p.R184C	TCGA-AA-3947	COAD	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.2778
p.R319H	TCGA-AA-3984	COAD	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.8244
p.R319H	TCGA-B5-A3FC	UCEC	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.8244
p.R319H	TCGA-BR-4184	STAD	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.8244
p.G1109R	TCGA-AB-2833	LAML	TCGA	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.M782V	TCGA-AP-A05N	UCEC	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.0556
p.E329K	TCGA-AP-A0LM	UCEC	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.1389
p.E329K	TCGA-CV-A6JN	HNSC	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.1389
p.P255H	TCGA-AP-A1DK	UCEC	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.S260I	TCGA-AX-A1CE	UCEC	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.2778
p.A759G	TCGA-AX-A1CE	UCEC	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.1944
p.R1129H	TCGA-AX-A2HD	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.0556
p.R1129H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.0556
p.P66L	TCGA-BH-A18U	BRCA	TCGA	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.0833
p.P192L	TCGA-BR-6802	STAD	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.0556
p.P1112H	TCGA-BR-8361	STAD	TCGA	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S262L	TCGA-CV-6942	HNSC	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.7667
p.S262L	SIDM01106	Melanoma	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.7667
p.S262L	SK-MEL-24	skin	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.7667
p.R208H	TCGA-D1-A17Q	UCEC	TCGA	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.8244
p.R208H	TCGA-G4-6588	COAD	TCGA	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.8244
p.P255S	TCGA-D3-A5GO	SKCM	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.P322S	TCGA-D3-A8GB	SKCM	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.6752
p.T186M	TCGA-D5-6930	COAD	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.2222
p.T186A	TCGA-DK-A6AW	BLCA	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.2222
p.V342I	TCGA-EC-A24G	UCEC	TCGA	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1667
p.T764I	TCGA-EE-A182	SKCM	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation altering degron motif	0.7078
p.S92F	TCGA-EE-A2MS	SKCM	TCGA	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.0833
p.V170F	TCGA-EO-A22U	UCEC	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.3056
p.R188Q	TCGA-EO-A3B0	UCEC	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.1667
p.S211T	TCGA-EY-A1GK	UCEC	TCGA	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.7116
p.T218M	TCGA-F7-A624	HNSC	TCGA	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.1389
p.R80H	TCGA-FD-A6TG	BLCA	TCGA	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.8244
p.P89S	TCGA-FR-A726	SKCM	TCGA	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1667
p.S773F	TCGA-FR-A726	SKCM	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.3056
p.P271S	TCGA-FW-A3R5	SKCM	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.2778
p.R208C	TCGA-G4-6304	COAD	TCGA	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.8301
p.A1115T	TCGA-UF-A7JS	HNSC	TCGA	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7139
p.R754Q	TCGA-VS-A94X	CESC	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.0556
p.E764Q	DO472	BLCA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation altering degron motif	0.6744
p.G1112D	DO575	BLCA	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.R272H	DO9002	COAD	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.25
p.R272H	DO232761	PBCA	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.25
p.R272H	DO38328	STAD	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.25
p.R272H	DO41871	UCEC	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.25
p.T183M	DO10443	COAD	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.3056
p.T183M	DO227979	COCA	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.3056
p.R161C	DO10639	COAD	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.0556
p.R161H	DO10140	COAD	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.0556
p.R161H	DO233864	GACA	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.0556
p.R161H	DO41903	UCEC	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.0556
p.E349K	DO9876	COAD	ICGC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7022
p.E349K	DO41903	UCEC	ICGC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7022
p.E349K	DO42608	UCEC	ICGC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7022
p.P321S	DO230309	COCA	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.6752
p.P81L	DO222755	COCA	ICGC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.7582
p.R1109Q	DO52495	COCA	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1667
p.T171M	DO234183	ESAD	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7423
p.T171M	DO44440	HNSC	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7423
p.G1128R	DO234401	ESAD	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.0833
p.R754C	DO233156	GACA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.0556
p.P342S	DO233652	GACA	ICGC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1667
p.C782S	DO233816	GACA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.0556
p.S220L	DO13863	GBM	ICGC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.0833
p.S220L	DO220861	MELA	ICGC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.0833
p.S215L	DO15951	HNSC	ICGC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.2222
p.S215L	SK-MEL-24	skin	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.2222
p.M779T	DO20837	KIRP	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.1389
p.G92C	DO228971	LICA	ICGC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.0833
p.E769D	DO229015	LICA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation altering degron motif	0.6758
p.R1127L	DO229029	LICA	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1111
p.V295F	DO229028	LICA	ICGC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.0833
p.E211D	DO229038	LICA	ICGC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.6758
p.R754L	DO229045	LICA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.0556
p.Q185H	DO229009	LICA	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.25
p.P353R	DO219552	LIHC	ICGC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7512
p.H319R	DO231531	LINC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.8244
p.L330Q	DO231602	LINC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.1111
p.R1121P	DO49876	LUAD	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2778
p.I253M	DO23858	LUAD	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.0833
p.L305F	DO26280	LUAD	ICGC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation altering degron motif	0.6981
p.L305F	DO37819	SKCM	ICGC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation altering degron motif	0.6981
p.P310L	DO26922	LUSC	ICGC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.3056
p.P310L	DO26922	LUSC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.1944
p.L755R	DO219174	LUSC	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.0833
p.S301Y	DO27120	LUSC	ICGC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation blocking phosphorylation signal	0.6944
p.V758G	DO52683	MALY	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.1667
p.G209C	DO222749	MELA	ICGC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.76
p.S313C	DO27991	OV	ICGC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.2222
p.S313C	DO27991	OV	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.2778
p.R1121S	DO28923	OV	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2778
p.P310H	DO35242	PACA	ICGC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.3056
p.P310H	DO35242	PACA	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.1944
p.A775V	DO36531	READ	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.25
p.E328K	DO220239	SARC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.1667
p.P76S	DO37567	SKCM	ICGC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.6752
p.P76S	SW684	soft tissue	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.6752
p.P275S	DO50280	SKCM	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.P208S	DO47419	SKCM	ICGC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.6752
p.R70H	DO38380	STAD	ICGC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1944
p.D760Y	DO47769	STAD	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.2222
p.A1115D	DO229275	THCA	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7793
p.K756N	DO229240	THCA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation blocking ubiquitination signal	0.5556
p.V295I	DO40996	UCEC	ICGC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.0833
p.P208H	DO42033	UCEC	ICGC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.7694
p.P208H	HCT-15	large intestine	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation altering degron motif	0.7694
p.S213I	DO42280	UCEC	ICGC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.2778
p.P81H	DO42280	UCEC	ICGC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.7694
p.R1127Q	DO42280	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1111
p.E1113K	DO43186	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2778
p.E1113K	DO42608	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2778
p.S164T	DO42985	UCEC	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.1389
p.N180I	DO41871	UCEC	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.728
p.R781H	DO41235	UCEC	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation blocking ubiquitination signal	0.5278
p.G92S	DO42472	UCEC	ICGC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.0833
p.N322D	DO41133	UCEC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.6932
p.D1117N	DO41331	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.6932
p.D1117N	NCI-H838	lung	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.6932
p.G196R	SIDM00373	Endometrial Carcinoma	GDSC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.0556
p.A328V	SIDM00455	Pancreatic Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.1667
p.A328V	PA-TU-8902	pancreas	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.1667
p.A85P	SIDM00845	Burkitt's Lymphoma	GDSC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2778
p.A85P	SIDM00035	Thyroid Gland Carcinoma	GDSC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2778
p.A85P	SIDM00461	Acute Myeloid Leukemia	GDSC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2778
p.A85P	Daudi	haematopoietic and lymphoid tissue	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2778
p.Y318C	SIDM01117	Small Cell Lung Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7087
p.Y318C	SIDM00087	Plasma Cell Myeloma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7087
p.Y318C	SIDM00654	Small Cell Lung Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7087
p.Y318C	SIDM01039	Other Solid Cancers	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7087
p.Y318C	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7087
p.Y318C	SIDM00621	Ewing's Sarcoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7087
p.Y318C	SIDM00673	Breast Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7087
p.Y318C	SIDM01409	Bladder Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7087
p.R319C	SIDM01175	Other Sarcomas	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.8301
p.R319C	SIDM00003	Melanoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.8301
p.R319C	SW684	soft tissue	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.8301
p.R319C	M14	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.8301
p.K181R	SIDM00157	Neuroblastoma	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7237
p.K181R	SIDM00293	Small Cell Lung Carcinoma	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7237
p.K181R	SIDM00363	Acute Myeloid Leukemia	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7237
p.K181R	LU-139	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7237
p.K181R	KP-N-YS	autonomic ganglia	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7237
p.K181R	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7237
p.P215H	SIDM00789	Colorectal Carcinoma	GDSC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.2222
p.P215H	HCT-15	large intestine	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.2222
p.T186P	SIDM00652	Small Cell Lung Carcinoma	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.2222
p.T186P	NCI-H1105	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.2222
p.P341Q	SIDM00676	Bladder Carcinoma	GDSC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1389
p.P252S	SIDM00806	Osteosarcoma	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.0556
p.P252S	HOS	bone	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.0556
p.R1121H	SIDM00844	Burkitt's Lymphoma	GDSC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2778
p.P271L	SIDM00621	Ewing's Sarcoma	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.2778
p.P271L	EW-13	bone	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.2778
p.G196E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.0556
p.G196E	NCI-H1573	lung	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.0556
p.T298A	SIDM00217	Colorectal Carcinoma	GDSC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.1667
p.T298A	SNU-1040	large intestine	COSMIC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.1667
p.P277R	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1111
p.P277R	PC-3_[JPC-3]	lung	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1111
p.E306D	SIDM01083	Oral Cavity Carcinoma	GDSC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation altering degron motif	0.5647
p.E306D	SCC-15	upper aerodigestive tract	COSMIC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation altering degron motif	0.5647
p.I178S	SIDM01448	Head and Neck Carcinoma	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7341
p.S173L	ACH-000032	Leukemia	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7667
p.S173L	ACH-001649	Prostate Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7667
p.A78P	ACH-000037	Sarcoma	CCLE	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.7503
p.A78P	Daudi	haematopoietic and lymphoid tissue	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.7503
p.E212D	ACH-000254	Head and Neck Cancer	CCLE	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.3056
p.E212D	SCC-15	upper aerodigestive tract	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.3056
p.I171S	ACH-000500	Head and Neck Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7341
p.Q778K	ACH-000620	Liver Cancer	CCLE	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.1667
p.R1110Q	ACH-000641	Leukemia	CCLE	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation blocking phosphorylation signal	0.6389
p.R1110Q	ACH-001036	Leukemia	CCLE	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation blocking phosphorylation signal	0.6389
p.R1110Q	CMK	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation blocking phosphorylation signal	0.6389
p.T179P	ACH-000780	Lung Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7031
p.T179P	NCI-H1105	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7031
p.S168L	ACH-000822	Skin Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.25
p.S168L	SK-MEL-24	skin	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.25
p.S189C	ACH-000934	Breast Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.1389
p.S189C	MDA-MB-361	breast	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.1389
p.T1124M	ACH-000961	Endometrial/Uterine Cancer	CCLE	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1944
p.R762H	ACH-000966	Ovarian Cancer	CCLE	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.2778
p.E302K	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.2778
p.T204A	ACH-000999	Colon/Colorectal Cancer	CCLE	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation blocking phosphorylation signal	0.7222
p.T204A	SNU-1040	large intestine	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation blocking phosphorylation signal	0.7222
p.G276D	ACH-000999	Colon/Colorectal Cancer	CCLE	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.G276D	SNU-1040	large intestine	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.T342I	ACH-001050	Sarcoma	CCLE	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1667
p.P177L	ACH-001509	Head and Neck Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7582
p.P177L	ACH-002113	Bone Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7582
p.P177L	EW-13	bone	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.7582
p.S301F	ACH-001675	Head and Neck Cancer	CCLE	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation blocking phosphorylation signal	0.6944
p.K777Q	ACH-002067	Bone Cancer	CCLE	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.1944
p.K777Q	NOS-1	bone	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.1944
p.E273K	ACH-002098	Skin Cancer	CCLE	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.2222
p.E273K	CP67-MEL	skin	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.2222
p.P769S	GP5d	large intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation altering degron motif	0.6752
p.S91L	SK-MEL-24	skin	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1111
p.R204G	GMS-10	central nervous system	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation blocking phosphorylation signal	0.7222
p.S80C	MDA-MB-361	breast	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.7541
p.E360K	CP67-MEL	skin	COSMIC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1389
p.E196K	CP67-MEL	skin	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.0556
p.E164K	CP67-MEL	skin	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.1389
p.G189E	NCI-H1573	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.1389
p.G323D	SNU-1040	large intestine	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.3056
p.R312C	M14	skin	COSMIC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.25
p.R312C	M14	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.25
p.R312C	SW684	soft tissue	COSMIC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.25
p.R312C	SW684	soft tissue	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation rewiring degron network	0.25
p.S276C	MDA-MB-361	breast	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.K174R	LU-139	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.6126
p.K174R	KP-N-YS	autonomic ganglia	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.6126
p.K174R	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation altering degron motif	0.6126
p.P770S	GP5d	large intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation altering degron motif	0.6752
p.Y80C	CW-2	large intestine	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.7087
p.P68L	EW-13	bone	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1389
p.L1111H	LCLC-97TM1	lung	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2222
p.G167D	SNU-1040	large intestine	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.2222
p.K87R	LU-139	lung	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2222
p.K87R	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2222
p.K87R	KP-N-YS	autonomic ganglia	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2222
p.P76L	SNU-C2B	large intestine	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.7582
p.R272C	M14	skin	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.25
p.R272C	SW684	soft tissue	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.25
p.K339Q	MDA-MB-436	breast	COSMIC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.0833
p.D1116N	NCI-H838	lung	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.6932
p.P168H	HCT-15	large intestine	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.25
p.P264L	EW-13	bone	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.6471
p.Y763C	HCT-15	large intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.3056
p.K778Q	NOS-1	bone	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.1667
p.R1118Q	TK10	kidney	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7329
p.A321V	PA-TU-8902	pancreas	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.5825
p.P270R	PC-3_[JPC-3]	lung	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.3056
p.R1118H	SNU-1040	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.8244
p.P183R	PC-3_[JPC-3]	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	171:182	Mutation rewiring degron network	0.3056
p.E259D	SCC-15	upper aerodigestive tract	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.25
p.G199D	SNU-1040	large intestine	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation rewiring degron network	0.1389
p.E299D	SCC-15	upper aerodigestive tract	COSMIC	SRETGE	DEG_Kelch_Keap1_1	304:309	Mutation rewiring degron network	0.1944
p.G363D	SNU-1040	large intestine	COSMIC	PTPLAS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.0556
p.T92P	NCI-H1105	lung	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.0833
p.S1121F	SNU-175	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2778
p.E320K	CP67-MEL	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	315:322	Mutation altering degron motif	0.7022
p.A765T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation altering degron motif	0.7139
p.P205S	HOS	bone	COSMIC	PTPPQT	DEG_SCF_FBW7_1	206:211	Mutation blocking phosphorylation signal	0.75
p.S255L	SK-MEL-24	skin	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.L1112H	LCLC-97TM1	lung	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.A766T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation altering degron motif	0.7139
p.P74R	PC-3_[JPC-3]	lung	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.3056
p.R1119H	SNU-1040	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.8244
p.P81S	HOS	bone	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.6752
p.Y762C	HCT-15	large intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.2778
p.S1122F	SNU-175	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.R754H	SNU-1040	large intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	764:772	Mutation rewiring degron network	0.0556
p.R80G	GMS-10	central nervous system	COSMIC	GPAAHVYPA	DEG_SIAH_1	75:83	Mutation altering degron motif	0.7568
p.R1111Q	CMK	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2222
p.R1117Q	TK10	kidney	COSMIC	PATST	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF4G1

UniProt ID: Q04637

Entrez ID: 1981

Protein name: Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF4G1 in