DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_SCF_FBW7_1

Location: 348:353

E3 ligase: FBXW7

DEGRON score: 0.9867

ASA_SCORE: 89.65

COIL: 0.9288

CONS_SCORE: 0.3215

DSS_SCORE: 0.6282

HELIX: 0.0432

FCONS_SCORE: 1.0016

RIG_SCORE: 0.6096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S360C	TCGA-13-1507	OV	TCGA	PTPLAS	DEG_SCF_FBW7_1	0.1389
p.S348Y	TCGA-21-5782	LUSC	TCGA	PTPLAS	DEG_SCF_FBW7_1	0.712
p.P357L	TCGA-22-4604	LUSC	TCGA	PTPLAS	DEG_SCF_FBW7_1	0.2222
p.L352F	TCGA-55-6982	LUAD	TCGA	PTPLAS	DEG_SCF_FBW7_1	0.6981
p.L352F	TCGA-EE-A2MR	SKCM	TCGA	PTPLAS	DEG_SCF_FBW7_1	0.6981
p.V342I	TCGA-EC-A24G	UCEC	TCGA	PTPLAS	DEG_SCF_FBW7_1	0.1667
p.E349K	DO9876	COAD	ICGC	PTPLAS	DEG_SCF_FBW7_1	0.7022
p.E349K	DO41903	UCEC	ICGC	PTPLAS	DEG_SCF_FBW7_1	0.7022
p.E349K	DO42608	UCEC	ICGC	PTPLAS	DEG_SCF_FBW7_1	0.7022
p.P342S	DO233652	GACA	ICGC	PTPLAS	DEG_SCF_FBW7_1	0.1667
p.P353R	DO219552	LIHC	ICGC	PTPLAS	DEG_SCF_FBW7_1	0.7512
p.P341Q	SIDM00676	Bladder Carcinoma	GDSC	PTPLAS	DEG_SCF_FBW7_1	0.1389
p.T342I	ACH-001050	Sarcoma	CCLE	PTPLAS	DEG_SCF_FBW7_1	0.1667
p.E360K	CP67-MEL	skin	COSMIC	PTPLAS	DEG_SCF_FBW7_1	0.1389
p.K339Q	MDA-MB-436	breast	COSMIC	PTPLAS	DEG_SCF_FBW7_1	0.0833
p.G363D	SNU-1040	large_intestine	COSMIC	PTPLAS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SCF_FBW7_1	348:353	PTPLAS	FBXW7	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons