DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_ODPH_VHL_1

Location: 171:182

E3 ligase: VHL

DEGRON score: 0.9187

ASA_SCORE: 124.8583

COIL: 0.9264

CONS_SCORE: 0.3359

DSS_SCORE: 0.7105

HELIX: 0.0468

FCONS_SCORE: 0.946

RIG_SCORE: 0.7455

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P169Q	TCGA-05-4396	LUAD	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.2778
p.R184C	TCGA-AA-3947	COAD	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.2778
p.P192L	TCGA-BR-6802	STAD	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.0556
p.T186M	TCGA-D5-6930	COAD	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.2222
p.T186A	TCGA-DK-A6AW	BLCA	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.2222
p.V170F	TCGA-EO-A22U	UCEC	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.3056
p.R188Q	TCGA-EO-A3B0	UCEC	TCGA	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.1667
p.T183M	DO10443	COAD	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.3056
p.T183M	DO227979	COCA	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.3056
p.R161C	DO10639	COAD	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.0556
p.R161H	DO10140	COAD	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.0556
p.R161H	DO233864	GACA	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.0556
p.R161H	DO41903	UCEC	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.0556
p.T171M	DO234183	ESAD	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7423
p.T171M	DO44440	HNSC	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7423
p.Q185H	DO229009	LICA	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.25
p.S164T	DO42985	UCEC	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.1389
p.N180I	DO41871	UCEC	ICGC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.728
p.K181R	SIDM00157	Neuroblastoma	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7237
p.K181R	SIDM00293	Small Cell Lung Carcinoma	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7237
p.K181R	SIDM00363	Acute Myeloid Leukemia	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7237
p.K181R	LU-139	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7237
p.K181R	KP-N-YS	autonomic_ganglia	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7237
p.K181R	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7237
p.T186P	SIDM00652	Small Cell Lung Carcinoma	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.2222
p.T186P	NCI-H1105	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.2222
p.I178S	SIDM01448	Head and Neck Carcinoma	GDSC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7341
p.S173L	ACH-000032	Leukemia	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7667
p.S173L	ACH-001649	Prostate Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7667
p.I171S	ACH-000500	Head and Neck Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7341
p.T179P	ACH-000780	Lung Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7031
p.T179P	NCI-H1105	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7031
p.S168L	ACH-000822	Skin Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.25
p.S168L	SK-MEL-24	skin	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.25
p.S189C	ACH-000934	Breast Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.1389
p.S189C	MDA-MB-361	breast	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.1389
p.P177L	ACH-001509	Head and Neck Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7582
p.P177L	ACH-002113	Bone Cancer	CCLE	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7582
p.P177L	EW-13	bone	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.7582
p.E164K	CP67-MEL	skin	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.1389
p.G189E	NCI-H1573	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.1389
p.K174R	LU-139	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.6126
p.K174R	KP-N-YS	autonomic_ganglia	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.6126
p.K174R	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.6126
p.G167D	SNU-1040	large_intestine	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.2222
p.P168H	HCT-15	large_intestine	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.25
p.P183R	PC-3_[JPC-3]	lung	COSMIC	IAPKRERKTIRI	DEG_ODPH_VHL_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPKRERKTIRI

Degron related mutations and impact score

Drug responses associated with EIF4G1 mutations

All proteins holding degron of IAPKRERKTIRI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_ODPH_VHL_1	171:182	IAPKRERKTIRI	VHL	0.9187	More...