DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_SIAH_1

Location: 75:83

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9635

ASA_SCORE: 84.2667

COIL: 0.9167

CONS_SCORE: 0.3398

DSS_SCORE: 0.4385

HELIX: 0.0338

FCONS_SCORE: 0.9944

RIG_SCORE: 0.6614

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A77T	TCGA-92-7341	LUSC	TCGA	GPAAHVYPA	DEG_SIAH_1	0.6028
p.P66L	TCGA-BH-A18U	BRCA	TCGA	GPAAHVYPA	DEG_SIAH_1	0.0833
p.S92F	TCGA-EE-A2MS	SKCM	TCGA	GPAAHVYPA	DEG_SIAH_1	0.0833
p.R80H	TCGA-FD-A6TG	BLCA	TCGA	GPAAHVYPA	DEG_SIAH_1	0.8244
p.P89S	TCGA-FR-A726	SKCM	TCGA	GPAAHVYPA	DEG_SIAH_1	0.1667
p.P81L	DO222755	COCA	ICGC	GPAAHVYPA	DEG_SIAH_1	0.7582
p.G92C	DO228971	LICA	ICGC	GPAAHVYPA	DEG_SIAH_1	0.0833
p.P76S	DO37567	SKCM	ICGC	GPAAHVYPA	DEG_SIAH_1	0.6752
p.P76S	SW684	soft_tissue	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.6752
p.R70H	DO38380	STAD	ICGC	GPAAHVYPA	DEG_SIAH_1	0.1944
p.P81H	DO42280	UCEC	ICGC	GPAAHVYPA	DEG_SIAH_1	0.7694
p.G92S	DO42472	UCEC	ICGC	GPAAHVYPA	DEG_SIAH_1	0.0833
p.A85P	SIDM00845	Burkitt's Lymphoma	GDSC	GPAAHVYPA	DEG_SIAH_1	0.2778
p.A85P	SIDM00035	Thyroid Gland Carcinoma	GDSC	GPAAHVYPA	DEG_SIAH_1	0.2778
p.A85P	SIDM00461	Acute Myeloid Leukemia	GDSC	GPAAHVYPA	DEG_SIAH_1	0.2778
p.A85P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.2778
p.A78P	ACH-000037	Sarcoma	CCLE	GPAAHVYPA	DEG_SIAH_1	0.7503
p.A78P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.7503
p.S91L	SK-MEL-24	skin	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.1111
p.S80C	MDA-MB-361	breast	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.7541
p.Y80C	CW-2	large_intestine	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.7087
p.P68L	EW-13	bone	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.1389
p.K87R	LU-139	lung	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.2222
p.K87R	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.2222
p.K87R	KP-N-YS	autonomic_ganglia	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.2222
p.P76L	SNU-C2B	large_intestine	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.7582
p.T92P	NCI-H1105	lung	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.0833
p.P74R	PC-3_[JPC-3]	lung	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.3056
p.P81S	HOS	bone	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.6752
p.R80G	GMS-10	central_nervous_system	COSMIC	GPAAHVYPA	DEG_SIAH_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GPAAHVYPA

Degron related mutations and impact score

Drug responses associated with EIF4G1 mutations

All proteins holding degron of GPAAHVYPA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SIAH_1	75:83	GPAAHVYPA	SIAH1,SIAH2,SIAH3	0.9635	More...