DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_SCF_FBW7_1

Location: 262:269

E3 ligase: FBXW7

DEGRON score: 0.9921

ASA_SCORE: 89.95

COIL: 0.9735

CONS_SCORE: 0.3721

DSS_SCORE: 0.8527

HELIX: 0.0093

FCONS_SCORE: 1.1607

RIG_SCORE: 0.4279

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S267L	TCGA-19-5956	GBM	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	0.6556
p.S267L	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	0.6556
p.S276F	TCGA-30-1855	OV	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	0.1389
p.P255H	TCGA-AP-A1DK	UCEC	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	0.1389
p.S260I	TCGA-AX-A1CE	UCEC	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	0.2778
p.S262L	TCGA-CV-6942	HNSC	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	0.7667
p.S262L	SIDM01106	Melanoma	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	0.7667
p.S262L	SK-MEL-24	skin	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.7667
p.P255S	TCGA-D3-A5GO	SKCM	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	0.1389
p.P271S	TCGA-FW-A3R5	SKCM	TCGA	PSPTPSPS	DEG_SCF_FBW7_1	0.2778
p.R272H	DO9002	COAD	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	0.25
p.R272H	DO232761	PBCA	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	0.25
p.R272H	DO38328	STAD	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	0.25
p.R272H	DO41871	UCEC	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	0.25
p.I253M	DO23858	LUAD	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	0.0833
p.P275S	DO50280	SKCM	ICGC	PSPTPSPS	DEG_SCF_FBW7_1	0.1667
p.P252S	SIDM00806	Osteosarcoma	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	0.0556
p.P252S	HOS	bone	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.0556
p.P271L	SIDM00621	Ewing's Sarcoma	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	0.2778
p.P271L	EW-13	bone	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.2778
p.P277R	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PSPTPSPS	DEG_SCF_FBW7_1	0.1111
p.P277R	PC-3_[JPC-3]	lung	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.1111
p.G276D	ACH-000999	Colon/Colorectal Cancer	CCLE	PSPTPSPS	DEG_SCF_FBW7_1	0.1389
p.G276D	SNU-1040	large_intestine	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.1389
p.E273K	ACH-002098	Skin Cancer	CCLE	PSPTPSPS	DEG_SCF_FBW7_1	0.2222
p.E273K	CP67-MEL	skin	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.2222
p.S276C	MDA-MB-361	breast	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.1389
p.R272C	M14	skin	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.25
p.R272C	SW684	soft_tissue	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.25
p.P264L	EW-13	bone	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.6471
p.P270R	PC-3_[JPC-3]	lung	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.3056
p.E259D	SCC-15	upper_aerodigestive_tract	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.25
p.S255L	SK-MEL-24	skin	COSMIC	PSPTPSPS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSPTPSPS

Degron related mutations and impact score

Drug responses associated with EIF4G1 mutations

All proteins holding degron of PSPTPSPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SCF_FBW7_1	262:269	PSPTPSPS	FBXW7	0.9921	More...