DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_SCF_FBW7_1

Location: 206:211

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 86.7833

COIL: 0.9513

CONS_SCORE: 0.3764

DSS_SCORE: 0.8328

HELIX: 0.0165

FCONS_SCORE: 1.0992

RIG_SCORE: 0.5718

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D198Y	TCGA-66-2758	LUSC	TCGA	PTPPQT	DEG_SCF_FBW7_1	0.1111
p.R208H	TCGA-D1-A17Q	UCEC	TCGA	PTPPQT	DEG_SCF_FBW7_1	0.8244
p.R208H	TCGA-G4-6588	COAD	TCGA	PTPPQT	DEG_SCF_FBW7_1	0.8244
p.S211T	TCGA-EY-A1GK	UCEC	TCGA	PTPPQT	DEG_SCF_FBW7_1	0.7116
p.T218M	TCGA-F7-A624	HNSC	TCGA	PTPPQT	DEG_SCF_FBW7_1	0.1389
p.R208C	TCGA-G4-6304	COAD	TCGA	PTPPQT	DEG_SCF_FBW7_1	0.8301
p.S220L	DO13863	GBM	ICGC	PTPPQT	DEG_SCF_FBW7_1	0.0833
p.S220L	DO220861	MELA	ICGC	PTPPQT	DEG_SCF_FBW7_1	0.0833
p.S215L	DO15951	HNSC	ICGC	PTPPQT	DEG_SCF_FBW7_1	0.2222
p.S215L	SK-MEL-24	skin	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.2222
p.E211D	DO229038	LICA	ICGC	PTPPQT	DEG_SCF_FBW7_1	0.6758
p.G209C	DO222749	MELA	ICGC	PTPPQT	DEG_SCF_FBW7_1	0.76
p.P208S	DO47419	SKCM	ICGC	PTPPQT	DEG_SCF_FBW7_1	0.6752
p.P208H	DO42033	UCEC	ICGC	PTPPQT	DEG_SCF_FBW7_1	0.7694
p.P208H	HCT-15	large_intestine	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.7694
p.S213I	DO42280	UCEC	ICGC	PTPPQT	DEG_SCF_FBW7_1	0.2778
p.G196R	SIDM00373	Endometrial Carcinoma	GDSC	PTPPQT	DEG_SCF_FBW7_1	0.0556
p.P215H	SIDM00789	Colorectal Carcinoma	GDSC	PTPPQT	DEG_SCF_FBW7_1	0.2222
p.P215H	HCT-15	large_intestine	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.2222
p.G196E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PTPPQT	DEG_SCF_FBW7_1	0.0556
p.G196E	NCI-H1573	lung	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.0556
p.E212D	ACH-000254	Head and Neck Cancer	CCLE	PTPPQT	DEG_SCF_FBW7_1	0.3056
p.E212D	SCC-15	upper_aerodigestive_tract	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.3056
p.T204A	ACH-000999	Colon/Colorectal Cancer	CCLE	PTPPQT	DEG_SCF_FBW7_1	0.7222
p.T204A	SNU-1040	large_intestine	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.7222
p.R204G	GMS-10	central_nervous_system	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.7222
p.E196K	CP67-MEL	skin	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.0556
p.G199D	SNU-1040	large_intestine	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.1389
p.P205S	HOS	bone	COSMIC	PTPPQT	DEG_SCF_FBW7_1	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPPQT

Degron related mutations and impact score

Drug responses associated with EIF4G1 mutations

All proteins holding degron of PTPPQT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SCF_FBW7_1	206:211	PTPPQT	FBXW7	0.9975	More...