DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_SCF_FBW7_2

Location: 315:322

E3 ligase: FBXW7

DEGRON score: 0.9908

ASA_SCORE: 101.9125

COIL: 0.9506

CONS_SCORE: 0.3452

DSS_SCORE: 0.5838

HELIX: 0.022

FCONS_SCORE: 1.0459

RIG_SCORE: 0.6776

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R319C	SIDM01175	Other Sarcomas	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.8301
p.R319C	SIDM00003	Melanoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.8301
p.R319C	SW684	soft_tissue	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.8301
p.R319C	M14	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.8301
p.R319H	TCGA-AA-3984	COAD	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.8244
p.R319H	TCGA-B5-A3FC	UCEC	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.8244
p.R319H	TCGA-BR-4184	STAD	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.8244
p.H319R	DO231531	LINC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.8244
p.Y318C	SIDM01117	Small Cell Lung Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00087	Plasma Cell Myeloma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00654	Small Cell Lung Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM01039	Other Solid Cancers	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00621	Ewing's Sarcoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00673	Breast Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM01409	Bladder Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.E320K	CP67-MEL	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.7022
p.N322D	DO41133	UCEC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.6932
p.P322S	TCGA-D3-A8GB	SKCM	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.6752
p.P321S	DO230309	COCA	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.6752
p.A321V	PA-TU-8902	pancreas	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.5825
p.G323D	SNU-1040	large_intestine	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.3056
p.S313C	DO27991	OV	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.2778
p.R312C	M14	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.25
p.R312C	SW684	soft_tissue	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.25

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Drug responses associated with EIF4G1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PEPTPLAE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SCF_FBW7_2	315:322	PEPTPLAE	FBXW7	0.9908	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEPTPLAE

Degron related mutations and impact score

Drug responses associated with EIF4G1 mutations

All proteins holding degron of PEPTPLAE