DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_SCF_FBW7_2

Location: 315:322

E3 ligase: FBXW7

DEGRON score: 0.9908

ASA_SCORE: 101.9125

COIL: 0.9506

CONS_SCORE: 0.3452

DSS_SCORE: 0.5838

HELIX: 0.022

FCONS_SCORE: 1.0459

RIG_SCORE: 0.6776

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R319H	TCGA-AA-3984	COAD	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.8244
p.R319H	TCGA-B5-A3FC	UCEC	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.8244
p.R319H	TCGA-BR-4184	STAD	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.8244
p.E329K	TCGA-AP-A0LM	UCEC	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.1389
p.E329K	TCGA-CV-A6JN	HNSC	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.1389
p.P322S	TCGA-D3-A8GB	SKCM	TCGA	PEPTPLAE	DEG_SCF_FBW7_2	0.6752
p.P321S	DO230309	COCA	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.6752
p.H319R	DO231531	LINC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.8244
p.L330Q	DO231602	LINC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.1111
p.P310L	DO26922	LUSC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.1944
p.S313C	DO27991	OV	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.2778
p.P310H	DO35242	PACA	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.1944
p.E328K	DO220239	SARC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.1667
p.N322D	DO41133	UCEC	ICGC	PEPTPLAE	DEG_SCF_FBW7_2	0.6932
p.A328V	SIDM00455	Pancreatic Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.1667
p.A328V	PA-TU-8902	pancreas	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.1667
p.Y318C	SIDM01117	Small Cell Lung Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00087	Plasma Cell Myeloma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00654	Small Cell Lung Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM01039	Other Solid Cancers	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00621	Ewing's Sarcoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM00673	Breast Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.Y318C	SIDM01409	Bladder Carcinoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.7087
p.R319C	SIDM01175	Other Sarcomas	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.8301
p.R319C	SIDM00003	Melanoma	GDSC	PEPTPLAE	DEG_SCF_FBW7_2	0.8301
p.R319C	SW684	soft_tissue	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.8301
p.R319C	M14	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.8301
p.G323D	SNU-1040	large_intestine	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.3056
p.R312C	M14	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.25
p.R312C	SW684	soft_tissue	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.25
p.A321V	PA-TU-8902	pancreas	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.5825
p.E320K	CP67-MEL	skin	COSMIC	PEPTPLAE	DEG_SCF_FBW7_2	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEPTPLAE

Degron related mutations and impact score

Drug responses associated with EIF4G1 mutations

All proteins holding degron of PEPTPLAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SCF_FBW7_2	315:322	PEPTPLAE	FBXW7	0.9908	More...