DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_APCC_DBOX_1

Location: 764:772

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6406

ASA_SCORE: 53.1778

COIL: 0.4083

CONS_SCORE: 0.7904

DSS_SCORE: 0.3297

HELIX: 0.583

FCONS_SCORE: 1.3926

RIG_SCORE: 0.8129

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M782V	TCGA-AP-A05N	UCEC	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	0.0556
p.A759G	TCGA-AX-A1CE	UCEC	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	0.1944
p.T764I	TCGA-EE-A182	SKCM	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	0.7078
p.S773F	TCGA-FR-A726	SKCM	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	0.3056
p.R754Q	TCGA-VS-A94X	CESC	TCGA	VRSILNKLT	DEG_APCC_DBOX_1	0.0556
p.E764Q	DO472	BLCA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.6744
p.R754C	DO233156	GACA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.0556
p.C782S	DO233816	GACA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.0556
p.M779T	DO20837	KIRP	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.1389
p.E769D	DO229015	LICA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.6758
p.R754L	DO229045	LICA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.0556
p.L755R	DO219174	LUSC	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.0833
p.V758G	DO52683	MALY	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.1667
p.A775V	DO36531	READ	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.25
p.D760Y	DO47769	STAD	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.2222
p.K756N	DO229240	THCA	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.5556
p.R781H	DO41235	UCEC	ICGC	VRSILNKLT	DEG_APCC_DBOX_1	0.5278
p.Q778K	ACH-000620	Liver Cancer	CCLE	VRSILNKLT	DEG_APCC_DBOX_1	0.1667
p.R762H	ACH-000966	Ovarian Cancer	CCLE	VRSILNKLT	DEG_APCC_DBOX_1	0.2778
p.K777Q	ACH-002067	Bone Cancer	CCLE	VRSILNKLT	DEG_APCC_DBOX_1	0.1944
p.K777Q	NOS-1	bone	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.1944
p.P769S	GP5d	large_intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.6752
p.P770S	GP5d	large_intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.6752
p.Y763C	HCT-15	large_intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.3056
p.K778Q	NOS-1	bone	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.1667
p.A765T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.7139
p.A766T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.7139
p.Y762C	HCT-15	large_intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.2778
p.R754H	SNU-1040	large_intestine	COSMIC	VRSILNKLT	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRSILNKLT

Degron related mutations and impact score

Drug responses associated with EIF4G1 mutations

All proteins holding degron of VRSILNKLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_APCC_DBOX_1	764:772	VRSILNKLT	APC,CDC20,FZR1	0.6406	More...