DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_Kelch_Keap1_1

Location: 304:309

E3 ligase: KEAP1

DEGRON score: 0.937

ASA_SCORE: 101.95

COIL: 0.9192

CONS_SCORE: 0.3079

DSS_SCORE: 0.6879

HELIX: 0.0372

FCONS_SCORE: 0.9122

RIG_SCORE: 0.6511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M297I	TCGA-17-Z031	LUAD	TCGA	SRETGE	DEG_Kelch_Keap1_1	0.1389
p.G294E	TCGA-18-4083	LUSC	TCGA	SRETGE	DEG_Kelch_Keap1_1	0.0556
p.I300M	TCGA-38-4632	LUAD	TCGA	SRETGE	DEG_Kelch_Keap1_1	0.2222
p.V295F	DO229028	LICA	ICGC	SRETGE	DEG_Kelch_Keap1_1	0.0833
p.L305F	DO26280	LUAD	ICGC	SRETGE	DEG_Kelch_Keap1_1	0.6981
p.L305F	DO37819	SKCM	ICGC	SRETGE	DEG_Kelch_Keap1_1	0.6981
p.P310L	DO26922	LUSC	ICGC	SRETGE	DEG_Kelch_Keap1_1	0.3056
p.S301Y	DO27120	LUSC	ICGC	SRETGE	DEG_Kelch_Keap1_1	0.6944
p.S313C	DO27991	OV	ICGC	SRETGE	DEG_Kelch_Keap1_1	0.2222
p.P310H	DO35242	PACA	ICGC	SRETGE	DEG_Kelch_Keap1_1	0.3056
p.V295I	DO40996	UCEC	ICGC	SRETGE	DEG_Kelch_Keap1_1	0.0833
p.T298A	SIDM00217	Colorectal Carcinoma	GDSC	SRETGE	DEG_Kelch_Keap1_1	0.1667
p.T298A	SNU-1040	large_intestine	COSMIC	SRETGE	DEG_Kelch_Keap1_1	0.1667
p.E306D	SIDM01083	Oral Cavity Carcinoma	GDSC	SRETGE	DEG_Kelch_Keap1_1	0.5647
p.E306D	SCC-15	upper_aerodigestive_tract	COSMIC	SRETGE	DEG_Kelch_Keap1_1	0.5647
p.E302K	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRETGE	DEG_Kelch_Keap1_1	0.2778
p.S301F	ACH-001675	Head and Neck Cancer	CCLE	SRETGE	DEG_Kelch_Keap1_1	0.6944
p.R312C	M14	skin	COSMIC	SRETGE	DEG_Kelch_Keap1_1	0.25
p.R312C	SW684	soft_tissue	COSMIC	SRETGE	DEG_Kelch_Keap1_1	0.25
p.E299D	SCC-15	upper_aerodigestive_tract	COSMIC	SRETGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_Kelch_Keap1_1	304:309	SRETGE	KEAP1	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons