DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 12043:12047

E3 ligase: SPOP

DEGRON score: 0.7282

ASA_SCORE: 82.38

COIL: 0.869

CONS_SCORE: 0

DSS_SCORE: 0.344

HELIX: 0.0128

FCONS_SCORE: 0

RIG_SCORE: 0.7427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R12039W	TCGA-AG-A002	READ	TCGA	PATST	DEG_SPOP_SBC_1	0.2222
p.R12039W	TCGA-D3-A2JK	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	0.2222
p.R12039W	DO222432	ESCA	ICGC	PATST	DEG_SPOP_SBC_1	0.2222
p.R12039W	DO37619	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	0.2222
p.A12044V	DO50337	ESAD	ICGC	PATST	DEG_SPOP_SBC_1	0.5825
p.R12038C	DO33176	PACA	ICGC	PATST	DEG_SPOP_SBC_1	0.1944
p.R12038L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1944
p.R12038L	SIDM00454	Rhabdomyosarcoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1944
p.S12046N	SIDM00333	Endometrial Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.7069
p.S12046N	ACH-000988	Endometrial/Uterine Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.7069
p.S12046N	MFE-319	endometrium	COSMIC	PATST	DEG_SPOP_SBC_1	0.7069
p.N12037K	SIDM00930	Osteosarcoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1667
p.N12037K	ACH-001715	Bone Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.1667
p.N12037K	CAL-72	bone	COSMIC	PATST	DEG_SPOP_SBC_1	0.1667
p.N12037T	ACH-002309	Sarcoma	CCLE	PATST	DEG_SPOP_SBC_1	0.1667
p.N12037T	SW684	soft_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PATST