DegronMD

Uniprot ID: O43561

Source protein: Linker for activation of T-cells family member 1

Source gene: LAT

Class: DEG_SPOP_SBC_1

Location: 170:174

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 78.94

COIL: 0.8734

CONS_SCORE: 0.521

DSS_SCORE: 0.5213

HELIX: 0.0736

FCONS_SCORE: 0.7063

RIG_SCORE: 0.6463

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A170T	DO42713	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.P173T	ACH-001408	Bladder Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.7031
p.V170L	TCGA-DF-A2KU	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.6765
p.A183V	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.5278
p.L184R	HEC-1	endometrium	COSMIC	PATST	DEG_SPOP_SBC_1	0.5
p.A176S	DO229041	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.A178T	TCGA-EO-A22R	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.2222
p.E178K	CRO-AP3	NS	COSMIC	PATST	DEG_SPOP_SBC_1	0.2222
p.P165R	DO233262	GACA	ICGC	PATST	DEG_SPOP_SBC_1	0.1944
p.E179K	CRO-AP3	NS	COSMIC	PATST	DEG_SPOP_SBC_1	0.1944
p.A180V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1667
p.A181V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1389
p.A182V	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1111

Showing 1 to 13 of 13 entries

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Drug responses associated with LAT mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PATST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...

Showing 1 to 20 of 20 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with LAT mutations

All proteins holding degron of PATST