DegronMD - E7ERA6(RNF223)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P40T	DO233270	GACA	ICGC	PGTPGSE	DEG_SCF_FBW7_2	37:43	Mutation altering degron motif	0.7031
p.P228S	DO233782	GACA	ICGC	PATST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1667
p.A31V	DO232761	PBCA	ICGC	PGTPGSE	DEG_SCF_FBW7_2	37:43	Mutation rewiring degron network	0.1667
p.P242S	DO37432	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2222
p.P242S	DO229245	THCA	ICGC	PATST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2222
p.R232W	DO229257	THCA	ICGC	PATST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.C51F	DO229229	THCA	ICGC	PGTPGSE	DEG_SCF_FBW7_2	37:43	Mutation rewiring degron network	0.1111
p.S29I	DO229250	THCA	ICGC	PGTPGSE	DEG_SCF_FBW7_2	37:43	Mutation rewiring degron network	0.1111
p.P231R	SIDM00969	Ovarian Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.S237R	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PATST	DEG_SPOP_SBC_1	234:238	Mutation altering degron motif	0.7427
p.R44K	ACH-000945	Lung Cancer	CCLE	PGTPGSE	DEG_SCF_FBW7_2	37:43	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons