DegronMD

Uniprot ID: E7ERA6

Source protein: RING finger protein 223

Source gene: RNF223

Class: DEG_SCF_FBW7_2

Location: 37:43

E3 ligase: FBXW7

DEGRON score: 0.9838

ASA_SCORE: 78.9286

COIL: 0.845

CONS_SCORE: 0.5127

DSS_SCORE: 0.62

HELIX: 0.132

FCONS_SCORE: 1.105

RIG_SCORE: 0.5144

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P40T	DO233270	GACA	ICGC	PGTPGSE	DEG_SCF_FBW7_2	0.7031
p.A31V	DO232761	PBCA	ICGC	PGTPGSE	DEG_SCF_FBW7_2	0.1667
p.C51F	DO229229	THCA	ICGC	PGTPGSE	DEG_SCF_FBW7_2	0.1111
p.S29I	DO229250	THCA	ICGC	PGTPGSE	DEG_SCF_FBW7_2	0.1111
p.R44K	ACH-000945	Lung Cancer	CCLE	PGTPGSE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E7ERA6	RING finger protein 223	DEG_SCF_FBW7_2	37:43	PGTPGSE	FBXW7	0.9838	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons