DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_SPOP_SBC_1

Location: 1438:1442

E3 ligase: SPOP

DEGRON score: 0.9888

ASA_SCORE: 80.58

COIL: 0.8906

CONS_SCORE: 0.4867

DSS_SCORE: 0.7956

HELIX: 0.0266

FCONS_SCORE: 1.1599

RIG_SCORE: 0.591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1451V	TCGA-A5-A0G1	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.0833
p.T1442I	TCGA-D3-A8GI	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	0.7078
p.A1447V	TCGA-WS-AB45	COAD	TCGA	PATST	DEG_SPOP_SBC_1	0.1944
p.R1438Q	DO7934	COAD	ICGC	PATST	DEG_SPOP_SBC_1	0.7329
p.R1438W	DO233209	GACA	ICGC	PATST	DEG_SPOP_SBC_1	0.8634
p.R1438W	DO233634	GACA	ICGC	PATST	DEG_SPOP_SBC_1	0.8634
p.V1450A	DO228220	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.A1443S	DO228948	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.3056
p.V1437L	DO228974	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.3056
p.P1444A	SIDM00961	Ewing's Sarcoma	GDSC	PATST	DEG_SPOP_SBC_1	0.2778
p.P1444A	SIDM00234	Other Solid Cancers	GDSC	PATST	DEG_SPOP_SBC_1	0.2778
p.P1444A	ACH-000210	Bone Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.2778
p.P1444A	ACH-002201	Cervical Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.2778
p.P1444A	CADO-ES1	bone	COSMIC	PATST	DEG_SPOP_SBC_1	0.2778
p.P1444A	TC-YIK	cervix	COSMIC	PATST	DEG_SPOP_SBC_1	0.2778
p.P1446Q	SIDM00654	Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.2222
p.P1446Q	SIDM00257	Neuroblastoma	GDSC	PATST	DEG_SPOP_SBC_1	0.2222
p.A1439V	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.5825
p.A1439V	NCI-H1437	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with WNK2 mutations

All proteins holding degron of PATST