DegronMD - Q7Z6B7(SRGAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1016S	TCGA-55-A4DF	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation rewiring degron network	0.0556
p.A1016S	DO45318	LUAD	ICGC	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation rewiring degron network	0.0556
p.T1006M	TCGA-67-3771	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation altering degron motif	0.8534
p.E994D	TCGA-77-8143	LUSC	TCGA	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1667
p.E994D	TCGA-77-8143	LUSC	TCGA	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation rewiring degron network	0.1111
p.S999Y	TCGA-A5-A0G2	UCEC	TCGA	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation blocking phosphorylation signal	0.75
p.S999Y	TCGA-A5-A0G2	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation blocking phosphorylation signal	0.6944
p.S999Y	DO41235	UCEC	ICGC	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation blocking phosphorylation signal	0.75
p.S999Y	DO41235	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation blocking phosphorylation signal	0.6944
p.P1002T	TCGA-A6-6781	COAD	TCGA	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation altering degron motif	0.7031
p.P1002T	TCGA-A6-6781	COAD	TCGA	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation altering degron motif	0.7031
p.S1008F	TCGA-AX-A05Z	UCEC	TCGA	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation blocking phosphorylation signal	0.6944
p.S1008F	TCGA-AX-A05Z	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation blocking phosphorylation signal	0.7222
p.P1011H	TCGA-D9-A149	SKCM	TCGA	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1667
p.P1011H	TCGA-D9-A149	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation rewiring degron network	0.1944
p.G1007V	DO51878	BLCA	ICGC	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.2778
p.G1007V	DO51878	BLCA	ICGC	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation rewiring degron network	0.3056
p.N998K	DO233734	GACA	ICGC	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.2778
p.N998K	DO233734	GACA	ICGC	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation rewiring degron network	0.2222
p.N1003D	DO233820	GACA	ICGC	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation altering degron motif	0.6932
p.N1003D	DO233820	GACA	ICGC	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation altering degron motif	0.6932
p.N1003H	DO220359	KICH	ICGC	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation altering degron motif	0.7423
p.N1003H	DO220359	KICH	ICGC	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation altering degron motif	0.7423
p.P1010S	DO46779	PAEN	ICGC	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation blocking phosphorylation signal	0.6389
p.P1010S	DO46779	PAEN	ICGC	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation blocking phosphorylation signal	0.6667
p.G1007A	DoTc2-4510	cervix	COSMIC	PTPATS	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.2778
p.G1007A	DoTc2-4510	cervix	COSMIC	PATST	DEG_SPOP_SBC_1	1002:1006	Mutation rewiring degron network	0.3056

Kaplan plot for SRGAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRGAP1

UniProt ID: Q7Z6B7

Entrez ID: 57522

Protein name: SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRGAP1 in