DegronMD

Uniprot ID: Q7Z6B7

Source protein: SLIT-ROBO Rho GTPase-activating protein 1

Source gene: SRGAP1

Class: DEG_SCF_FBW7_1

Location: 1000:1005

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 86.85

COIL: 0.9527

CONS_SCORE: 0.2991

DSS_SCORE: 0.6437

HELIX: 0.023

FCONS_SCORE: 0.9256

RIG_SCORE: 0.6166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E994D	TCGA-77-8143	LUSC	TCGA	PTPATS	DEG_SCF_FBW7_1	0.1667
p.S999Y	TCGA-A5-A0G2	UCEC	TCGA	PTPATS	DEG_SCF_FBW7_1	0.75
p.S999Y	DO41235	UCEC	ICGC	PTPATS	DEG_SCF_FBW7_1	0.75
p.P1002T	TCGA-A6-6781	COAD	TCGA	PTPATS	DEG_SCF_FBW7_1	0.7031
p.S1008F	TCGA-AX-A05Z	UCEC	TCGA	PTPATS	DEG_SCF_FBW7_1	0.6944
p.P1011H	TCGA-D9-A149	SKCM	TCGA	PTPATS	DEG_SCF_FBW7_1	0.1667
p.G1007V	DO51878	BLCA	ICGC	PTPATS	DEG_SCF_FBW7_1	0.2778
p.N998K	DO233734	GACA	ICGC	PTPATS	DEG_SCF_FBW7_1	0.2778
p.N1003D	DO233820	GACA	ICGC	PTPATS	DEG_SCF_FBW7_1	0.6932
p.N1003H	DO220359	KICH	ICGC	PTPATS	DEG_SCF_FBW7_1	0.7423
p.P1010S	DO46779	PAEN	ICGC	PTPATS	DEG_SCF_FBW7_1	0.6389
p.G1007A	DoTc2-4510	cervix	COSMIC	PTPATS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SCF_FBW7_1	1000:1005	PTPATS	FBXW7	0.9911	More...
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SCF_FBW7_1	989:994	PTPATS	FBXW7	0.9207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons