DegronMD

Uniprot ID: Q6ZRI6

Source protein: Uncharacterized protein C15orf39

Source gene: C15orf39

Class: DEG_SCF_FBW7_1

Location: 989:994

E3 ligase: FBXW7

DEGRON score: 0.9207

ASA_SCORE: 87.2667

COIL: 0.9573

CONS_SCORE: 0.3147

DSS_SCORE: 0.6905

HELIX: 0.0202

FCONS_SCORE: 0.8486

RIG_SCORE: 0.5757

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G999S	TCGA-32-1977	GBM	TCGA	PTPATS	DEG_SCF_FBW7_1	0.1944
p.G999S	DO12076	GBM	ICGC	PTPATS	DEG_SCF_FBW7_1	0.1944
p.A979T	TCGA-DI-A1BU	UCEC	TCGA	PTPATS	DEG_SCF_FBW7_1	0.0556
p.A979T	DO42023	UCEC	ICGC	PTPATS	DEG_SCF_FBW7_1	0.0556
p.P991T	TCGA-EE-A2MD	SKCM	TCGA	PTPATS	DEG_SCF_FBW7_1	0.7031
p.P991T	DO37851	SKCM	ICGC	PTPATS	DEG_SCF_FBW7_1	0.7031
p.P991L	TCGA-YD-A9TA	SKCM	TCGA	PTPATS	DEG_SCF_FBW7_1	0.7582
p.P991L	DO219503	SKCM	ICGC	PTPATS	DEG_SCF_FBW7_1	0.7582
p.P991H	DO233882	GACA	ICGC	PTPATS	DEG_SCF_FBW7_1	0.7694
p.P991H	ACH-000548	Head and Neck Cancer	CCLE	PTPATS	DEG_SCF_FBW7_1	0.7694
p.G999D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTPATS	DEG_SCF_FBW7_1	0.1944
p.G999D	ACH-000995	Leukemia	CCLE	PTPATS	DEG_SCF_FBW7_1	0.1944
p.A992V	ACH-001028	Rhabdoid	CCLE	PTPATS	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SCF_FBW7_1	1000:1005	PTPATS	FBXW7	0.9911	More...
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SCF_FBW7_1	989:994	PTPATS	FBXW7	0.9207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons