DegronMD - Q6ZRI6(C15orf39)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G999S	TCGA-32-1977	GBM	TCGA	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation rewiring degron network	0.1944
p.G999S	DO12076	GBM	ICGC	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation rewiring degron network	0.1944
p.P745T	TCGA-51-4079	LUSC	TCGA	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1111
p.P745T	DO26437	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1111
p.D761N	TCGA-AN-A0AT	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.D761N	DO2783	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.T941A	TCGA-AP-A1DK	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.25
p.T941A	DO42033	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.25
p.K44N	TCGA-AX-A1CE	UCEC	TCGA	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation blocking ubiquitination signal	0.5556
p.K44N	DO42280	UCEC	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation blocking ubiquitination signal	0.5556
p.A958T	TCGA-B5-A1MX	UCEC	TCGA	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.0556
p.A958T	DO41999	UCEC	ICGC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.0556
p.G76S	TCGA-CA-6717	COAD	TCGA	PPLY	ITCH	70:73	Mutation rewiring degron network	0.25
p.G76S	DO8264	COAD	ICGC	PPLY	ITCH	70:73	Mutation rewiring degron network	0.25
p.G926C	TCGA-D3-A2JH	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1111
p.G926C	DO47263	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1111
p.G45W	TCGA-D3-A2JL	SKCM	TCGA	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.1389
p.G45W	DO47278	SKCM	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.1389
p.P56L	TCGA-D3-A8GI	SKCM	TCGA	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.7582
p.P56L	DO50284	SKCM	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.7582
p.A979T	TCGA-DI-A1BU	UCEC	TCGA	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation rewiring degron network	0.0556
p.A979T	TCGA-DI-A1BU	UCEC	TCGA	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1944
p.A979T	DO42023	UCEC	ICGC	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation rewiring degron network	0.0556
p.A979T	DO42023	UCEC	ICGC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1944
p.P81Q	TCGA-EE-A2GE	SKCM	TCGA	PPLY	ITCH	70:73	Mutation rewiring degron network	0.1111
p.P81Q	DO38016	SKCM	ICGC	PPLY	ITCH	70:73	Mutation rewiring degron network	0.1111
p.P991T	TCGA-EE-A2MD	SKCM	TCGA	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation altering degron motif	0.7031
p.P991T	DO37851	SKCM	ICGC	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation altering degron motif	0.7031
p.M77I	TCGA-EE-A2MG	SKCM	TCGA	PPLY	ITCH	70:73	Mutation rewiring degron network	0.2222
p.M77I	DO37421	SKCM	ICGC	PPLY	ITCH	70:73	Mutation rewiring degron network	0.2222
p.V942A	TCGA-EO-A22U	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.2222
p.V942A	DO43755	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.2222
p.K960E	TCGA-EO-A22U	UCEC	TCGA	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation substituting flanking lysine	0.2222
p.K960E	DO43755	UCEC	ICGC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation substituting flanking lysine	0.2222
p.G54S	TCGA-FR-A726	SKCM	TCGA	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.5882
p.G54S	DO48665	SKCM	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.5882
p.A749T	TCGA-G4-6588	COAD	TCGA	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.A749T	DO10140	COAD	ICGC	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.A749T	SIDM01048	Plasma Cell Myeloma	GDSC	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.A749T	ACH-000821	Myeloma	CCLE	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.E946K	TCGA-KL-8342	KICH	TCGA	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1111
p.E946K	DO220350	KICH	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1111
p.E931K	TCGA-UY-A9PB	BLCA	TCGA	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.25
p.E931K	DO219041	BLCA	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.25
p.R20H	TCGA-VQ-A91E	STAD	TCGA	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.2222
p.R20H	DO51784	STAD	ICGC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.2222
p.D504N	TCGA-XF-AAML	BLCA	TCGA	LAPYRD	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1944
p.D504N	DO51933	BLCA	ICGC	LAPYRD	LIG_APCC_ABBA_1	509:514	Mutation rewiring degron network	0.1944
p.P991L	TCGA-YD-A9TA	SKCM	TCGA	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation altering degron motif	0.7582
p.P991L	DO219503	SKCM	ICGC	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation altering degron motif	0.7582
p.P70T	DO222874	COCA	ICGC	PPLY	ITCH	70:73	Mutation altering degron motif	0.7031
p.G945D	DO229010	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1389
p.G945D	DO229013	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1389
p.G945D	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1389
p.G945D	DO229003	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1389
p.G945D	DO229005	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1389
p.V933L	DO234151	ESAD	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.3056
p.M52V	DO233270	GACA	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.6097
p.P991H	DO233882	GACA	ICGC	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation altering degron motif	0.7694
p.P991H	ACH-000548	Head and Neck Cancer	CCLE	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation altering degron motif	0.7694
p.P971H	DO233903	GACA	ICGC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation altering degron motif	0.7694
p.A958S	DO228976	LICA	ICGC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.0556
p.R20L	DO229018	LICA	ICGC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.2222
p.E61D	DO229015	LICA	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.2778
p.E61D	DO229015	LICA	ICGC	PPLY	ITCH	70:73	Mutation rewiring degron network	0.0833
p.V961F	DO229029	LICA	ICGC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1389
p.D39Y	DO229028	LICA	ICGC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.0833
p.D514V	DO231772	LINC	ICGC	LAPYRD	LIG_APCC_ABBA_1	509:514	Mutation altering degron motif	0.7785
p.P751S	DO220901	MELA	ICGC	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2778
p.S762F	DO222875	MELA	ICGC	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.S936Y	DO232838	NACA	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation altering degron motif	0.712
p.E948K	DO232832	NACA	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.0556
p.A937S	DO36881	READ	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation altering degron motif	0.7588
p.G929V	DO37543	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1944
p.P964S	DO229257	THCA	ICGC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.2222
p.A53V	DO234133	THCA	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.5825
p.A53V	SIDM01878	Non-Cancerous	GDSC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.5825
p.A53V	SIDM00053	Pancreatic Carcinoma	GDSC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.5825
p.A934S	DO42977	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation altering degron motif	0.7588
p.M14I	SIDM00683	Prostate Carcinoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.0556
p.M14I	ACH-000977	lymph node	CCLE	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.0556
p.R962G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962G	ACH-000981	Leukemia	CCLE	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.G999D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation rewiring degron network	0.1944
p.G999D	ACH-000995	Leukemia	CCLE	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation rewiring degron network	0.1944
p.E939D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.3056
p.E939D	ACH-000995	Leukemia	CCLE	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.3056
p.P973L	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation altering degron motif	0.6471
p.P973L	ACH-002272	Lymphoma	CCLE	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation altering degron motif	0.6471
p.R20C	SIDM00107	Melanoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.2222
p.R20C	SIDM00477	Esophageal Carcinoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.2222
p.R20C	SIDM00154	Mesothelioma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.2222
p.R962K	SIDM00267	Biliary Tract Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM00556	Neuroblastoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM01061	Oral Cavity Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM00591	Oral Cavity Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM00604	Oral Cavity Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM01569	Hepatocellular Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM00167	Head and Neck Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM01394	Kidney Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM00784	Glioma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM01435	Hepatocellular Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM00173	Head and Neck Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.R962K	SIDM01343	Gastric Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	968:974	Mutation rewiring degron network	0.1667
p.S938L	SIDM00636	Non-Cancerous	GDSC	AVSSS	DEG_SPOP_SBC_1	934:938	Mutation altering degron motif	0.7667
p.H33Y	SIDM00847	Rhabdomyosarcoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.25
p.H33Y	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.25
p.P753A	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	753:757	Mutation altering degron motif	0.6392
p.P51H	SIDM00217	Colorectal Carcinoma	GDSC	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.3056
p.P51H	ACH-000999	Colon/Colorectal Cancer	CCLE	MAGTPKAE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.3056
p.V35I	SIDM00228	Thyroid Gland Carcinoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.1944
p.V35I	ACH-000897	Thyroid Cancer	CCLE	DSGLEHS	DEG_SCF_TRCP1_1	24:30	Mutation rewiring degron network	0.1944
p.E764A	ACH-000994	Endometrial/Uterine Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1389
p.A992V	ACH-001028	Rhabdoid	CCLE	PTPATS	DEG_SCF_FBW7_1	989:994	Mutation altering degron motif	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C15orf39

UniProt ID: Q6ZRI6

Entrez ID: 56905

Protein name: Uncharacterized protein C15orf39

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for C15orf39 in