DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LAPYRD
Uniprot ID:
Q6ZRI6
Source protein:
Uncharacterized protein C15orf39
Source gene:
C15orf39
Class:
LIG_APCC_ABBA_1
Location:
509:514
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9686
ASA_SCORE:
72.65
COIL:
0.8273
CONS_SCORE:
0.9259
DSS_SCORE:
0.4481
HELIX:
0.0827
FCONS_SCORE:
1.2721
RIG_SCORE:
0.7653
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D504N
TCGA-XF-AAML
BLCA
TCGA
LAPYRD
LIG_APCC_ABBA_1
0.1944
p.D504N
DO51933
BLCA
ICGC
LAPYRD
LIG_APCC_ABBA_1
0.1944
p.D514V
DO231772
LINC
ICGC
LAPYRD
LIG_APCC_ABBA_1
0.7785
Drug responses associated with C15orf39 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPYRD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZRI6
Uncharacterized protein C15orf39
LIG_APCC_ABBA_1
509:514
LAPYRD
APC,CDC20,FZR1
0.9686
More...