DegronMD

Uniprot ID: Q6ZRI6

Source protein: Uncharacterized protein C15orf39

Source gene: C15orf39

Class: DEG_SCF_TRCP1_1

Location: 24:30

E3 ligase: BTRC

DEGRON score: 0.9775

ASA_SCORE: 75.6143

COIL: 0.8279

CONS_SCORE: 0.5907

DSS_SCORE: 0.5248

HELIX: 0.1093

FCONS_SCORE: 0.9849

RIG_SCORE: 0.6591

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H33Y	SIDM00847	Rhabdomyosarcoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	0.25
p.H33Y	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	0.25
p.R20H	TCGA-VQ-A91E	STAD	TCGA	DSGLEHS	DEG_SCF_TRCP1_1	0.2222
p.R20H	DO51784	STAD	ICGC	DSGLEHS	DEG_SCF_TRCP1_1	0.2222
p.R20L	DO229018	LICA	ICGC	DSGLEHS	DEG_SCF_TRCP1_1	0.2222
p.R20C	SIDM00107	Melanoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	0.2222
p.R20C	SIDM00477	Esophageal Carcinoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	0.2222
p.R20C	SIDM00154	Mesothelioma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	0.2222
p.V35I	SIDM00228	Thyroid Gland Carcinoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	0.1944
p.V35I	ACH-000897	Thyroid Cancer	CCLE	DSGLEHS	DEG_SCF_TRCP1_1	0.1944
p.D39Y	DO229028	LICA	ICGC	DSGLEHS	DEG_SCF_TRCP1_1	0.0833
p.M14I	SIDM00683	Prostate Carcinoma	GDSC	DSGLEHS	DEG_SCF_TRCP1_1	0.0556
p.M14I	ACH-000977	lymph_node	CCLE	DSGLEHS	DEG_SCF_TRCP1_1	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SCF_TRCP1_1	24:30	DSGLEHS	BTRC	0.9775	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons