DegronMD

Uniprot ID: Q6ZRI6

Source protein: Uncharacterized protein C15orf39

Source gene: C15orf39

Class: DEG_SCF_FBW7_2

Location: 968:974

E3 ligase: FBXW7

DEGRON score: 0.9776

ASA_SCORE: 93.2

COIL: 0.9431

CONS_SCORE: 0.6861

DSS_SCORE: 0.7827

HELIX: 0.033

FCONS_SCORE: 1.661

RIG_SCORE: 0.5171

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A958T	TCGA-B5-A1MX	UCEC	TCGA	PPTPGPE	DEG_SCF_FBW7_2	0.0556
p.A958T	DO41999	UCEC	ICGC	PPTPGPE	DEG_SCF_FBW7_2	0.0556
p.A979T	TCGA-DI-A1BU	UCEC	TCGA	PPTPGPE	DEG_SCF_FBW7_2	0.1944
p.A979T	DO42023	UCEC	ICGC	PPTPGPE	DEG_SCF_FBW7_2	0.1944
p.K960E	TCGA-EO-A22U	UCEC	TCGA	PPTPGPE	DEG_SCF_FBW7_2	0.2222
p.K960E	DO43755	UCEC	ICGC	PPTPGPE	DEG_SCF_FBW7_2	0.2222
p.P971H	DO233903	GACA	ICGC	PPTPGPE	DEG_SCF_FBW7_2	0.7694
p.A958S	DO228976	LICA	ICGC	PPTPGPE	DEG_SCF_FBW7_2	0.0556
p.V961F	DO229029	LICA	ICGC	PPTPGPE	DEG_SCF_FBW7_2	0.1389
p.P964S	DO229257	THCA	ICGC	PPTPGPE	DEG_SCF_FBW7_2	0.2222
p.R962G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962G	ACH-000981	Leukemia	CCLE	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.P973L	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.6471
p.P973L	ACH-002272	Lymphoma	CCLE	PPTPGPE	DEG_SCF_FBW7_2	0.6471
p.R962K	SIDM00267	Biliary Tract Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM00556	Neuroblastoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM01061	Oral Cavity Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM00591	Oral Cavity Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM00604	Oral Cavity Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM01569	Hepatocellular Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM00167	Head and Neck Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM01394	Kidney Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM00784	Glioma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM01435	Hepatocellular Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM00173	Head and Neck Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667
p.R962K	SIDM01343	Gastric Carcinoma	GDSC	PPTPGPE	DEG_SCF_FBW7_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPGPE

Degron related mutations and impact score

Drug responses associated with C15orf39 mutations

All proteins holding degron of PPTPGPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SCF_FBW7_2	968:974	PPTPGPE	FBXW7	0.9776	More...