DegronMD

Uniprot ID: Q6ZRI6

Source protein: Uncharacterized protein C15orf39

Source gene: C15orf39

Class: DEG_SCF_FBW7_2

Location: 52:59

E3 ligase: FBXW7

DEGRON score: 0.9622

ASA_SCORE: 73.65

COIL: 0.833

CONS_SCORE: 0.4985

DSS_SCORE: 0.3702

HELIX: 0.1044

FCONS_SCORE: 0.7787

RIG_SCORE: 0.6973

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P56L	TCGA-D3-A8GI	SKCM	TCGA	MAGTPKAE	DEG_SCF_FBW7_2	0.7582
p.P56L	DO50284	SKCM	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	0.7582
p.M52V	DO233270	GACA	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	0.6097
p.G54S	TCGA-FR-A726	SKCM	TCGA	MAGTPKAE	DEG_SCF_FBW7_2	0.5882
p.G54S	DO48665	SKCM	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	0.5882
p.A53V	DO234133	THCA	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	0.5825
p.A53V	SIDM01878	Non-Cancerous	GDSC	MAGTPKAE	DEG_SCF_FBW7_2	0.5825
p.A53V	SIDM00053	Pancreatic Carcinoma	GDSC	MAGTPKAE	DEG_SCF_FBW7_2	0.5825
p.K44N	TCGA-AX-A1CE	UCEC	TCGA	MAGTPKAE	DEG_SCF_FBW7_2	0.5556
p.K44N	DO42280	UCEC	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	0.5556
p.P51H	SIDM00217	Colorectal Carcinoma	GDSC	MAGTPKAE	DEG_SCF_FBW7_2	0.3056
p.P51H	ACH-000999	Colon/Colorectal Cancer	CCLE	MAGTPKAE	DEG_SCF_FBW7_2	0.3056
p.E61D	DO229015	LICA	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	0.2778
p.G45W	TCGA-D3-A2JL	SKCM	TCGA	MAGTPKAE	DEG_SCF_FBW7_2	0.1389
p.G45W	DO47278	SKCM	ICGC	MAGTPKAE	DEG_SCF_FBW7_2	0.1389

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SCF_FBW7_2	52:59	MAGTPKAE	FBXW7	0.9622	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons