DegronMD - P38935(IGHMBP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q678H	TCGA-AP-A1DK	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.1944
p.Q678H	DO42033	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.1944
p.R679W	TCGA-BG-A0LX	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.1667
p.R679W	DO41919	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.1667
p.S677G	TCGA-BR-6454	STAD	TCGA	PATST	DEG_SPOP_SBC_1	669:673	Mutation blocking phosphorylation signal	0.6667
p.S677G	DO38595	STAD	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation blocking phosphorylation signal	0.6667
p.P802L	TCGA-D9-A6EC	SKCM	TCGA	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1667
p.P802L	DO50291	SKCM	ICGC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1667
p.T671A	DO223837	AML	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO221233	AML	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO229010	COCA	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO229003	COCA	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO229005	COCA	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO234205	ESAD	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO229346	LAML	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO229489	LAML	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO52365	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO231007	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.T671A	DO220917	WT	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.7139
p.P818H	DO50090	COAD	ICGC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.25
p.G682E	DO233107	GACA	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.0833
p.R679Q	DO233737	GACA	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.1667
p.R679L	DO229045	LICA	ICGC	PATST	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.1667
p.P804S	DO47331	SKCM	ICGC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.2222
p.R823C	SIDM02015	Colorectal Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1111
p.R823C	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1111
p.R823C	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1111
p.R823C	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1111
p.R823C	LC-1-sq	lung	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1111
p.R823C	TE-6	oesophagus	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1111
p.R823C	KYSE-180	oesophagus	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1111
p.G801C	SIDM01129	Small Cell Lung Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1389
p.G801C	ACH-000816	Lung Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1389
p.G801C	NCI-H524	lung	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1389
p.G801V	SIDM01129	Small Cell Lung Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1389
p.G801V	ACH-000816	Lung Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1389
p.G801V	NCI-H524	lung	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1389
p.P809L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation altering degron motif	0.6471
p.P809L	ACH-002062	Lymphoma	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation altering degron motif	0.6471
p.P809L	SLVL	haematopoietic and lymphoid tissue	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation altering degron motif	0.6471
p.P819L	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.2222
p.P819L	ACH-000823	Esophageal Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.2222
p.P819L	KYSE-140	oesophagus	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.2222
p.G801S	SIDM00093	Ovarian Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1389
p.G801S	ACH-000013	Ovarian Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.1389
p.Q806H	ACH-000723	Head and Neck Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	808:815	Mutation rewiring degron network	0.2778

Kaplan plot for IGHMBP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGHMBP2

UniProt ID: P38935

Entrez ID: 3508

Protein name: DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGHMBP2 in