DegronMD

Uniprot ID: P38935

Source protein: DNA-binding protein SMUBP-2

Source gene: IGHMBP2

Class: DEG_SCF_FBW7_1

Location: 808:815

E3 ligase: FBXW7

DEGRON score: 0.7618

ASA_SCORE: 90.55

COIL: 0.9269

CONS_SCORE: 0.1128

DSS_SCORE: 0.9298

HELIX: 0.0589

FCONS_SCORE: 0.9479

RIG_SCORE: 0.5465

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P802L	TCGA-D9-A6EC	SKCM	TCGA	VPPTPAQT	DEG_SCF_FBW7_1	0.1667
p.P802L	DO50291	SKCM	ICGC	VPPTPAQT	DEG_SCF_FBW7_1	0.1667
p.P818H	DO50090	COAD	ICGC	VPPTPAQT	DEG_SCF_FBW7_1	0.25
p.P804S	DO47331	SKCM	ICGC	VPPTPAQT	DEG_SCF_FBW7_1	0.2222
p.R823C	SIDM02015	Colorectal Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.1111
p.R823C	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.1111
p.R823C	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.1111
p.R823C	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.1111
p.R823C	LC-1-sq	lung	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	0.1111
p.R823C	TE-6	oesophagus	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	0.1111
p.R823C	KYSE-180	oesophagus	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	0.1111
p.G801C	SIDM01129	Small Cell Lung Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.1389
p.G801C	ACH-000816	Lung Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	0.1389
p.G801C	NCI-H524	lung	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	0.1389
p.G801V	SIDM01129	Small Cell Lung Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.1389
p.G801V	ACH-000816	Lung Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	0.1389
p.G801V	NCI-H524	lung	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	0.1389
p.P809L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.6471
p.P809L	ACH-002062	Lymphoma	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	0.6471
p.P809L	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	0.6471
p.P819L	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.2222
p.P819L	ACH-000823	Esophageal Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	0.2222
p.P819L	KYSE-140	oesophagus	COSMIC	VPPTPAQT	DEG_SCF_FBW7_1	0.2222
p.G801S	SIDM00093	Ovarian Carcinoma	GDSC	VPPTPAQT	DEG_SCF_FBW7_1	0.1389
p.G801S	ACH-000013	Ovarian Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	0.1389
p.Q806H	ACH-000723	Head and Neck Cancer	CCLE	VPPTPAQT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPPTPAQT

Degron related mutations and impact score

Drug responses associated with IGHMBP2 mutations

All proteins holding degron of VPPTPAQT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38935	DNA-binding protein SMUBP-2	DEG_SCF_FBW7_1	808:815	VPPTPAQT	FBXW7	0.7618	More...